Validation of a novel computerized cognitive function test for the rapid detection of mild cognitive impairment

<jats:title>Abstract</jats:title><jats:sec> <jats:title>Background</jats:title> <jats:p>In the present study, we examined the distinguishing ability of a mild cognitive impairment (MCI) assessment tool for rapid screening using a computer (MARC) for Alzheimer’s disease dementia (ADD), MCI, and non-demented controls (NDC) with no cognitive impairment, as well as its validity and reliability, as part of a preliminary trial for the development of the tool.</jats:p> </jats:sec><jats:sec> <jats:title>Methods</jats:title> <jats:p>A total of 64 participants (23 in the ADD group, 17 in the MCI group, and 24 in the NDC group) were analyzed. The participants were administered MARC and a pre-existing computerized Alzheimer’s dementia screening test (MSP), and 31 participants (14 in the MCI group, 17 in the NDC group) were readministered MARC within 4 months from the first test.</jats:p> </jats:sec><jats:sec> <jats:title>Results</jats:title> <jats:p>The median (interquartile range) test time for MARC was 401 (350–453) s. Total MARC scores were significantly worse in the MCI and ADD groups than in the NDC group (<jats:italic>p</jats:italic> < 0.05 and <jats:italic>p</jats:italic> < 0.01, respectively). In the receiver operating characteristic (ROC) analysis, the area under the ROC curve (AUC) when comparing the NDC and MCI groups was 0.866 (95% CI, 0.759–0.974), when comparing the NDC and AD groups was 0.989 (95% CI, 0.970–1.000), and when comparing the MCI and AD groups was 0.889 (95% CI, 0.790–0.988). Furthermore, there was a significant correlation with the results of the existing test, MSP (r = 0.839, <jats:italic>p</jats:italic> < 0.001). In addition, the intraclass correlation coefficient (ICC) (1,1) when the first and second MARC scores were compared was 0.740 (95% CI, 0.529–0.865; <jats:italic>p</jats:italic> < 0.001).</jats:p> </jats:sec><jats:sec> <jats:title>Conclusions</jats:title> <jats:p>MARC is considered capable of distinguishing MCI with high accuracy. The tool has good validity and reliability, and it can be administered in a short period of time without the need for a specialist.</jats:p> </jats:sec>