Significance of Circulating Remnant Lipoprotein Cholesterol Levels Measured by Homogeneous Assay in Patients with Type 2 Diabetes

DOI Web Site 参考文献37件 オープンアクセス
  • Kazumi Matsushima-Nagata
    Department of Medical Technology, Kumamoto Health Science University, Kumamoto 861-5598, Japan
  • Takeshi Matsumura
    Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Kumamoto 860-8556, Japan
  • Yuki Kondo
    Department of Clinical Chemistry and Informatics, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto 862-0973, Japan
  • Kensaku Anraku
    Department of Medical Technology, Kumamoto Health Science University, Kumamoto 861-5598, Japan
  • Kazuki Fukuda
    Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Kumamoto 860-8556, Japan
  • Mikihiro Yamanaka
    Research and Development/Technology Research Laboratory, Shimadzu Corporation, Kyoto 604-8511, Japan
  • Masahiro Manabe
    Department of Laboratory Medicine, Kumamoto University Hospital, Kumamoto 860-8556, Japan
  • Tetsumi Irie
    Department of Clinical Chemistry and Informatics, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto 862-0973, Japan
  • Eiichi Araki
    Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Kumamoto 860-8556, Japan
  • Hiroyuki Sugiuchi
    Department of Medical Technology, Kumamoto Health Science University, Kumamoto 861-5598, Japan

抄録

<jats:p>Remnant lipoproteins (RLs), which are typically present at high concentrations in patients with type 2 diabetes mellitus (T2DM), are associated with cardiovascular disease (CVD). Although an RL cholesterol homogeneous assay (RemL-C) is available for the measurement of RL concentrations, there have been no studies of the relationship between RemL-C and clinical parameters in T2DM. Therefore, we evaluated the relationships between RemL-C and CVD-related parameters in patients with T2DM. We performed a cross-sectional study of 169 patients with T2DM who were hospitalized at Kumamoto University Hospital. Compared with those with low RemL-C, those with higher RemL-C had higher fasting plasma glucose, homeostasis model assessment for insulin resistance (HOMA-R), total cholesterol, triglyceride, small dense low-density lipoprotein cholesterol (sdLDL-C), and urinary albumin-creatinine ratio; and lower high-density lipoprotein cholesterol, adiponectin, and ankle brachial pressure index (ABI). Multivariate logistic regression analysis showed that sdLDL-C and ABI were significantly and independently associated with high RemL-C. Although LDL-C was lower in participants with CVD, there was no difference in RemL-C between participants with or without CVD. Thus, RemL-C may represent a useful index of lipid and glucose metabolism, and that may be a marker of peripheral atherosclerotic disease (PAD) in male patients with T2DM.</jats:p>

収録刊行物

  • Biomolecules

    Biomolecules 13 (3), 468-, 2023-03-03

    MDPI AG

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