Evolution of Vertebrate Hormones and Their Receptors: Insights from Non-Osteichthyan Genomes
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- Shigehiro Kuraku
- Molecular Life History Laboratory, Department of Genomics and Evolutionary Biology, National Institute of Genetics, Mishima, Japan;
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- Hiroyuki Kaiya
- Grandsoul Research Institute of Immunology, Inc., Uda, Japan
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- Tomohiro Tanaka
- Department of Gastroenterology and Metabolism, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Japan
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- Susumu Hyodo
- Laboratory of Physiology, Atmosphere and Ocean Research Institute, The University of Tokyo, Kashiwa, Japan
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説明
<jats:p> Homeostatic control and reproductive functions of humans are regulated at the molecular levels largely by peptide hormones secreted from endocrine and/or neuroendocrine cells in the central nervous system and peripheral organs. Homologs of those hormones and their receptors function similarly in many vertebrate species distantly related to humans, but the evolutionary history of the endocrine system involving those factors has been obscured by the scarcity of genome DNA sequence information of some taxa that potentially contain their orthologs. Focusing on non-osteichthyan vertebrates, namely jawless and cartilaginous fishes, this article illustrates how investigating genome sequence information assists our understanding of the diversification of vertebrate gene repertoires in four broad themes: ( a) the presence or absence of genes, ( b) multiplication and maintenance of paralogs, ( c) differential fates of duplicated paralogs, and ( d) the evolutionary timing of gene origins. </jats:p>
収録刊行物
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- Annual Review of Animal Biosciences
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Annual Review of Animal Biosciences 11 (1), 163-182, 2023-02-15
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