In vivo [18F]THK-5351 imaging detected reactive astrogliosis in argyrophilic grain disease with comorbid pathology: A clinicopathological study
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- Ryota Kobayashi
- Department of Psychiatry, Yamagata University School of Medicine , Yamagata, Japan
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- Tadaho Nakamura
- Division of Pharmacology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University , Sendai, Japan
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- Fumito Naganuma
- Division of Pharmacology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University , Sendai, Japan
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- Ryuichi Harada
- Department of Pharmacology, Tohoku University Graduate School of Medicine , Sendai, Japan
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- Daichi Morioka
- Department of Psychiatry, Yamagata University School of Medicine , Yamagata, Japan
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- Masafumi Kanoto
- Department of Diagnostic Radiology, Yamagata University School of Medicine , Yamagata, Japan
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- Shozo Furumoto
- Cyclotron and Radioisotope Center, Tohoku University , Sendai, Japan
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- Yukitsuka Kudo
- Department of New Therapeutics Innovation for Alzheimer’s and Dementia, Institute of Development and Aging, Tohoku University , Sendai, Japan
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- Takanobu Kabasawa
- Department of Pathology, Yamagata University School of Medicine , Yamagata, Japan
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- Koichi Otani
- Department of Psychiatry, Yamagata University School of Medicine , Yamagata, Japan
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- Mitsuru Futakuchi
- Department of Pathology, Yamagata University School of Medicine , Yamagata, Japan
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- Shinobu Kawakatsu
- Department of Neuropsychiatry, Aizu Medical Center, Fukushima Medical University , Aizuwakamatsu, Japan
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- Nobuyuki Okamura
- Division of Pharmacology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University , Sendai, Japan
説明
<jats:title>Abstract</jats:title> <jats:p>Quantification of in vivo reactive astrogliosis, which represents neural inflammation and remodeling in the brain, is an emerging methodology for the evaluation of patients with neurodegenerative diseases. [18F]THK-5351 is a positron emission tomography (PET) tracer for monoamine oxidase B (MAO-B), a molecular marker of reactive astrogliosis. We performed in vivo [18F]THK-5351 PET in a patient who at autopsy was found to have argyrophilic grain disease (AGD) with comorbid pathology to visualize reactive astrogliosis for the first time. We aimed to validate an imaging-pathology correlation using [18F]THK-5351 PET and the autopsy brain. The patient, a 78-year-old man, was pathologically diagnosed with AGD combined with limbic-predominant age-related transactive response DNA-binding protein of 43 kDa encephalopathy and Lewy body disease without Alzheimer disease-related neuropathological changes. Reactive astrogliosis in the postmortem brain was abundant in the inferior temporal gyrus, insular gyrus, entorhinal cortex, and ambient gyrus where premortem [18F]THK-5351 signals were high. We found a proportional correlation between the amount of reactive astrogliosis in the postmortem brain and the in vivo [18F]THK-5351 standardized uptake value ratio (r = 0.8535, p = 0.0004). These results indicated that reactive astrogliosis in AGD with comorbid pathology could be identified and quantified by in vivo MAO-B imaging.</jats:p>
収録刊行物
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- Journal of Neuropathology & Experimental Neurology
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Journal of Neuropathology & Experimental Neurology 82 (5), 427-437, 2023-03-07
Oxford University Press (OUP)
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詳細情報 詳細情報について
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- CRID
- 1360580230588347136
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- ISSN
- 15546578
- 00223069
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