Risk factors for liver‐related mortality of patients with hepatitis C virus after sustained virologic response to direct‐acting antiviral agents
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- Nobuhiro Hattori
- Department of Internal Medicine, Division of Gastroenterology and Hepatology St. Marianna University School of Medicine Kawasaki Japan
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- Hiroki Ikeda
- Department of Internal Medicine, Division of Gastroenterology and Hepatology St. Marianna University School of Medicine Kawasaki Japan
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- Tsunamasa Watanabe
- Department of Internal Medicine, Division of Gastroenterology and Hepatology St. Marianna University School of Medicine Kawasaki Japan
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- Yosuke Satta
- Department of Internal Medicine, Division of Gastroenterology and Hepatology St. Marianna University School of Medicine Kawasaki Japan
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- Takuya Ehira
- Department of Internal Medicine, Division of Gastroenterology and Hepatology St. Marianna University School of Medicine Kawasaki Japan
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- Tatsuya Suzuki
- Department of Internal Medicine, Division of Gastroenterology and Hepatology St. Marianna University School of Medicine Kawasaki Japan
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- Hirofumi Kiyokawa
- Department of Internal Medicine, Division of Gastroenterology and Hepatology St. Marianna University School of Medicine Kawasaki Japan
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- Kazunari Nakahara
- Department of Internal Medicine, Division of Gastroenterology and Hepatology St. Marianna University School of Medicine Kawasaki Japan
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- Hideaki Takahashi
- Division of Gastroenterology and Hepatology St. Marianna University Yokohama Seibu Hospital Yokohama Japan
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- Kotaro Matsunaga
- Division of Gastroenterology and Hepatology Kawasaki Municipal Tama Hospital Kawasaki Japan
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- Nobuyuki Matsumoto
- Division of Gastroenterology and Hepatology St. Marianna University Yokohama Seibu Hospital Yokohama Japan
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- Hiroshi Yasuda
- Department of Internal Medicine, Division of Gastroenterology and Hepatology St. Marianna University School of Medicine Kawasaki Japan
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- Michihiro Suzuki
- Division of Gastroenterology and Hepatology Kawasaki Municipal Tama Hospital Kawasaki Japan
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- Fumio Itoh
- Department of Internal Medicine, Division of Gastroenterology and Hepatology St. Marianna University School of Medicine Kawasaki Japan
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- Keisuke Tateishi
- Department of Internal Medicine, Division of Gastroenterology and Hepatology St. Marianna University School of Medicine Kawasaki Japan
Abstract
<jats:title>Abstract</jats:title><jats:sec><jats:title>Background and Aim</jats:title><jats:p>The aim of this study was to identify the factors associated with liver‐related and non‐liver‐related mortality of patients with hepatitis C virus (HCV) after sustained virologic response (SVR) to direct‐acting antiviral agents (DAAs).</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>We conducted a retrospective, single‐center cohort study of HCV patients cured by DAAs.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>A total of 330 patients with SVR to DAAs were eligible. The median follow‐up period was 3.38 years (inter‐quartile range: 2.03–4.58). The cumulative liver‐related or non‐liver‐related mortality rates at 1, 3, and 5 years were 0.00 or 1.29%, 2.87 or 3.60%, and 5.10 or 9.46, respectively. Among the liver‐related deaths, 9 of the 10 were from liver cancer. Among the non‐liver‐related deaths, the most common cause was malignancy. Through multivariate analysis using the Cox proportional hazard model, diabetes mellitus (DM, hazard ratio 13.1, 95% confidence interval 2.81–61.3) and a history of hepatocellular carcinoma (HCC, 12.8, 2.76–59.2), independently predicted liver‐related death. No variables were associated with non‐liver‐related death.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Our findings suggest that DM and a history of HCC are risk factors for liver‐related mortality of HCV patients cured by DAAs. These results indicate that early management of HCV and HCC surveillance of diabetic patients after SVR are important to increase the chance of survival. Further studies are needed to confirm the association of DM and HCC history with survival.</jats:p></jats:sec>
Journal
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- JGH Open
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JGH Open 6 (10), 685-691, 2022-08-26
Wiley
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Keywords
Details 詳細情報について
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- CRID
- 1360580230595566720
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- ISSN
- 23979070
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- Data Source
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- Crossref
- KAKEN