Enantioselective Synthesis of (+)-Agelasidine A Using Thio-Claisen Rearrangement

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<jats:title>Abstract</jats:title><jats:p>Enantioselective synthesis of the marine natural product (+)-agelasidine A has been achieved by taking advantage of [1,3]-chirality transfer from enantiomerically enriched α-silyl farnesol through a key thio-Claisen rearrangement. The optical rotation of the hydrochloride salt of the synthetic substance confirmed that natural (+)-agelasidine A has the S-configuration at its C-10 stereogenic center.</jats:p>

Journal

  • Synthesis

    Synthesis 54 (19), 4347-4352, 2022-06-28

    Georg Thieme Verlag KG

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