Cross‐sectional association of metrics derived from continuous glucose monitoring with cognitive performance in older adults with type 2 diabetes

  • Taiki Sugimoto
    Department of Prevention and Care Science, Research Institute National Center for Geriatrics and Gerontology Obu Japan
  • Haruhiko Tokuda
    Department of Clinical Laboratory, Hospital National Center for Geriatrics and Gerontology Obu Japan
  • Hisayuki Miura
    Department of Endocrinology and Metabolism, Hospital National Center for Geriatrics and Gerontology Obu Japan
  • Shuji Kawashima
    Department of Endocrinology and Metabolism, Hospital National Center for Geriatrics and Gerontology Obu Japan
  • Takafumi Ando
    Human‐Centered Mobility Research Center National Institute of Advanced Industrial Science and Technology Tsukuba Japan
  • Yujiro Kuroda
    Department of Prevention and Care Science, Research Institute National Center for Geriatrics and Gerontology Obu Japan
  • Nanae Matsumoto
    Department of Prevention and Care Science, Research Institute National Center for Geriatrics and Gerontology Obu Japan
  • Kosuke Fujita
    Department of Prevention and Care Science, Research Institute National Center for Geriatrics and Gerontology Obu Japan
  • Kazuaki Uchida
    Department of Prevention and Care Science, Research Institute National Center for Geriatrics and Gerontology Obu Japan
  • Yoshinobu Kishino
    Department of Prevention and Care Science, Research Institute National Center for Geriatrics and Gerontology Obu Japan
  • Takashi Sakurai
    Department of Prevention and Care Science, Research Institute National Center for Geriatrics and Gerontology Obu Japan

抄録

<jats:title>Abstract</jats:title><jats:sec><jats:title>Aim</jats:title><jats:p>To examine the association between continuous glucose monitoring (CGM)‐derived metrics and cognitive performance in older adults with type 2 diabetes (T2D).</jats:p></jats:sec><jats:sec><jats:title>Materials and methods</jats:title><jats:p>A total of 100 outpatients with T2D aged 70 years or older were analysed. Participants underwent CGM for 14 days. As CGM‐derived metrics, mean sensor glucose (SG), glucose coefficient of variation (CV), time in range (TIR; 70‐180 mg/dl), time above range (TAR; > 180 mg/dl) and time below range (TBR; < 70 mg/dl), were calculated. Participants underwent cognitive tests, including the Japanese version of the Montreal Cognitive Assessment (MoCA‐J), a delayed word‐recall test from the Alzheimer's Disease Assessment Scale‐cognitive subscale, a digit symbol substitution test, a letter word fluency test, a trail‐making test (TMT) and digit span test (DSP).</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>In multiple regression analyses adjusted for confounders, a higher mean SG was associated with a lower performance in MoCA‐J and TMT part B (TMT‐B) (<jats:italic>P</jats:italic> < .05). A higher TAR was associated with a lower performance in TMT‐B and DSP‐backward (<jats:italic>P</jats:italic> < .05). By contrast, a higher TIR was associated with better function in TMT‐B and DSP‐backward (<jats:italic>P</jats:italic> < .05). Furthermore, CV and TBR were not associated with any cognitive function.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Hyperglycaemia metrics and TIR derived from CGM are associated with cognitive functions, especially with executive function and working memory, in older adults with T2D.</jats:p></jats:sec>

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