Clinical Practice Guidelines for Hepatocellular Carcinoma: The Japan Society of Hepatology 2021 version (5th JSH‐HCC Guidelines)

  • Kiyoshi Hasegawa
    Hepato‐Biliary‐Pancreatic Surgery Division Department of Surgery Graduate School of Medicine University of Tokyo Tokyo Japan
  • Nobuyuki Takemura
    Department of Surgery Hepato‐Biliary Pancreatic Surgery Division National Center for Global Health and Medicine Tokyo Japan
  • Tatsuya Yamashita
    Department of Gastroenterology Kanazawa University Hospital Kanazawa Japan
  • Takeyuki Watadani
    Department of Radiology Graduate School of Medicine The University of Tokyo Tokyo Japan
  • Masaki Kaibori
    Department of Surgery Hirakata Hospital Kansai Medical University Hirakata Japan
  • Shoji Kubo
    Department of Hepato‐Biliary‐Pancreatic Surgery Osaka Metropolitan University Graduate School of Medicine Osaka Japan
  • Mitsuo Shimada
    Department of Digestive and Transplant Surgery Tokushima University Hospital Tokushima Japan
  • Hiroaki Nagano
    Department of Gastroenterological, Breast and Endocrine Surgery Yamaguchi University Graduate School of Medicine Yamaguchi Japan
  • Etsuro Hatano
    Division of Hepato‐Biliary‐Pancreatic Surgery and Transplantation Department of Surgery Graduate School of Medicine Kyoto University Kyoto Japan
  • Hiroshi Aikata
    Department of Medicine and Molecular Science Hiroshima University Hospital Hiroshima Japan
  • Hiroko Iijima
    Division of Gastroenterology and Hepatobiliary Department of Internal Medicine Hyogo Medical University Nishinomiya Japan
  • Kazuomi Ueshima
    Department of Gastroenterology and Hepatology Kindai University Faculty of Medicine Higashi‐osaka Japan
  • Kazuyoshi Ohkawa
    Department of Hepatobiliary and Pancreatic Oncology Osaka International Cancer Institute Osaka Japan
  • Takuya Genda
    Department of Gastroenterology and Hepatology Juntendo University Shizuoka Hospital Izunokuni Japan
  • Kaoru Tsuchiya
    Department of Gastroenterology and Hepatology Musashino Red Cross Hospital Musashino Japan
  • Takuji Torimura
    Division of Gastroenterology Department of Medicine Kurume University School of Medicine Kurume Japan
  • Masafumi Ikeda
    Department of Hepatobiliary and Pancreatic Oncology National Cancer Center Hospital East Kashiwa Japan
  • Junji Furuse
    Department of Gastroenterology Kanagawa Cancer Center Yokohama Japan
  • Masaaki Akahane
    Department of Radiology School of Medicine International University of Health and Welfare Otawara Japan
  • Satoshi Kobayashi
    Department of Quantum Medical Technology Kanazawa University Graduate School of Medical Sciences Kanazawa Japan
  • Hideyuki Sakurai
    Department of Radiation Oncology University of Tsukuba Faculty of Medicine Tsukuba Japan
  • Atsuya Takeda
    Radiation Oncology Center Ofuna Chuo Hospital Kamakura Japan
  • Takamichi Murakami
    Department of Radiology Kobe University Graduate School of Medicine Hyogo Japan
  • Utaroh Motosugi
    Department of Diagnostic Radiology Kofu Kyoritsu Hospital Kofu Japan
  • Yutaka Matsuyama
    Department of Biostatistics School of Public Health Graduate School of Medicine The University of Tokyo Tokyo Japan
  • Masatoshi Kudo
    Department of Gastroenterology and Hepatology Kindai University Faculty of Medicine Higashi‐osaka Japan
  • Ryosuke Tateishi
    Department of Gastroenterology Graduate School of Medicine The University of Tokyo Tokyo Japan

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<jats:title>Abstract</jats:title><jats:p>The fifth version of the Clinical Practice Guidelines for Hepatocellular Carcinoma was revised by the Japan Society of Hepatology, according to the methodology of evidence‐based medicine and partly to the Grading of Recommendations Assessment, Development and Evaluation system, which was published in October 2021 in Japanese. In addition to surveillance–diagnostic and treatment algorithms, a new algorithm for systemic therapy has been created, as multiple drugs for hepatocellular carcinoma can be currently selected. Here, new or revised algorithms and evidence on which the recommendations are based are described.</jats:p>

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