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- Ayako Edahiro
- Tokyo Metropolitan Institute of Gerontology Tokyo Japan
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- Tsuyoshi Okamura
- Tokyo Metropolitan Institute of Gerontology Tokyo Japan
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- Tetsuaki Arai
- Department of Psychiatry, Division of Clinical Medicine University of Tsukuba Tsukuba Japan
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- Takeshi Ikeuchi
- Department of Molecular Genetics, Brain Research Institute Niigata University Niigata Japan
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- Manabu Ikeda
- Department of Psychiatry Osaka University Graduate School of Medicine Suita Japan
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- Kumiko Utsumi
- Department of Psychiatry Sunagawa City Medical Centre Sunagawa Japan
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- Hidetaka Ota
- Advanced Research Centre for Geriatric and Gerontology Akita University Akita Japan
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- Tatsuyuki Kakuma
- Biostatistics Centre Kurume University School of Medicine Kurume Japan
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- Shinobu Kawakatsu
- Department of Neuropsychiatry, Aizu Medical Centre Fukushima Medical University Aizu Japan
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- Yoko Konagaya
- Japanese Psychogeriatric Society Japan
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- Kyoko Suzuki
- Department of Behavioural Neurology and Cognitive Neuroscience Tohoku University School of Medicine Sendai Japan
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- Satoshi Tanimukai
- Department of Comprehensive Community Care for Elderly, Nursing and Health Science, Graduate School of Medicine Ehime University Toon Japan
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- Kazuo Miyanaga
- Yukiguni‐Yamato Dementia Care Centre Yukiguni‐Yamato Hospital Niigata Japan
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- Shuichi Awata
- Tokyo Metropolitan Institute of Gerontology Tokyo Japan
抄録
<jats:sec><jats:title>Aim</jats:title><jats:p>The aim of this study was to investigate initial symptoms of early‐onset dementia (EOD) for each dementia subtype.</jats:p></jats:sec><jats:sec><jats:title>Method</jats:title><jats:p>We conducted a nationwide, population‐based EOD prevalence study in Japan. Data were collected through service providers for people with EOD. Initial symptoms were assessed in six domains: loss of memory, difficulty in word generation, irritability, loss of motivation, increased mistakes in the workplace or domestically, and unusual behaviours or attitudes other than those listed.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Participants were 770 people with EOD. Characteristic initial symptoms were observed for each EOD subtype. Loss of memory was more common in early‐onset Alzheimer's disease (75.7%, <jats:italic>P</jats:italic> < 0.001), difficulty in word generation was more common in early‐onset vascular dementia (41.3%, <jats:italic>P</jats:italic> < 0.001), and loss of motivation, increased mistakes in the workplace or domestically, and unusual behaviours or attitudes other than those listed were more common in early‐onset frontotemporal dementia (34.9%, <jats:italic>P</jats:italic> < 0.001; 49.4%, <jats:italic>P</jats:italic> < 0.001; 34.9%, <jats:italic>P</jats:italic> < 0.001, respectively). In addition, we observed gender differences whereby loss of memory was more common among women and irritability was more common among men. More than half of the participants were employed at symptom onset, and 57.2% of those who were employed at the onset had initial symptoms of increased mistakes in the workplace or domestically.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>This report reveals differences in the frequency of initial symptoms by EOD subtype. The results contribute to increasing public awareness of the initial symptoms of EOD, which will facilitate early diagnosis and social support.</jats:p></jats:sec>
収録刊行物
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- Psychogeriatrics
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Psychogeriatrics 23 (3), 422-433, 2023-02-22
Wiley
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詳細情報 詳細情報について
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- CRID
- 1360580232156881536
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- ISSN
- 14798301
- 13463500
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- データソース種別
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- Crossref
- KAKEN