Dynamic capillary stalls in reperfused ischemic penumbra contribute to injury: A hyperacute role for neutrophils in persistent traffic jams

DOI Web Site Web Site 被引用文献2件
  • Şefik E Erdener
    Neurophotonics Center, Department of Biomedical Engineering, Boston University, Boston, MA, USA
  • Jianbo Tang
    Neurophotonics Center, Department of Biomedical Engineering, Boston University, Boston, MA, USA
  • Kıvılcım Kılıç
    Neurophotonics Center, Department of Biomedical Engineering, Boston University, Boston, MA, USA
  • Dmitry Postnov
    Neurophotonics Center, Department of Biomedical Engineering, Boston University, Boston, MA, USA
  • John T Giblin
    Neurophotonics Center, Department of Biomedical Engineering, Boston University, Boston, MA, USA
  • Sreekanth Kura
    Neurophotonics Center, Department of Biomedical Engineering, Boston University, Boston, MA, USA
  • I-chun A Chen
    Neurophotonics Center, Department of Biomedical Engineering, Boston University, Boston, MA, USA
  • Tuğberk Vayisoğlu
    Neurophotonics Center, Department of Biomedical Engineering, Boston University, Boston, MA, USA
  • Sava Sakadžić
    Optics Division, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA
  • Chris B Schaffer
    Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA
  • David A Boas
    Neurophotonics Center, Department of Biomedical Engineering, Boston University, Boston, MA, USA

書誌事項

公開日
2020-04-01
権利情報
  • https://journals.sagepub.com/page/policies/text-and-data-mining-license
DOI
  • 10.1177/0271678x20914179
公開者
SAGE Publications

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説明

<jats:p> Ever since the introduction of thrombolysis and the subsequent expansion of endovascular treatments for acute ischemic stroke, it remains to be identified why the actual outcomes are less favorable despite recanalization. Here, by high spatio-temporal resolution imaging of capillary circulation in mice, we introduce the pathological phenomenon of dynamic flow stalls in cerebral capillaries, occurring persistently in salvageable penumbra after reperfusion. These stalls, which are different from permanent cellular plugs of no-reflow, were temporarily and repetitively occurring in the capillary network, impairing the overall circulation like small focal traffic jams. In vivo microscopy in the ischemic penumbra revealed leukocytes traveling slowly through capillary lumen or getting stuck, while red blood cell flow was being disturbed in the neighboring segments under reperfused conditions. Stall dynamics could be modulated, by injection of an anti-Ly6G antibody specifically targeting neutrophils. Decreased number and duration of stalls were associated with improvement in penumbral blood flow within 2–24 h after reperfusion along with increased capillary oxygenation, decreased cellular damage and improved functional outcome. Thereby, dynamic microcirculatory stall phenomenon can be a contributing factor to ongoing penumbral injury and is a potential hyperacute mechanism adding on previous observations of detrimental effects of activated neutrophils in ischemic stroke. </jats:p>

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