Dual‐Mechanism Antimicrobial Polymer–ZnO Nanoparticle and Crystal Violet‐Encapsulated Silicone

DOI Web Site Web Site 被引用文献1件
  • Sacha Noimark
    Materials Chemistry Research Centre Department of Chemistry University College London 20 Gordon St London WC1H 0AJ UK
  • Jonathan Weiner
    Department of Chemistry Imperial College London London SW7 2AZ UK
  • Nuruzzaman Noor
    Materials Chemistry Research Centre Department of Chemistry University College London 20 Gordon St London WC1H 0AJ UK
  • Elaine Allan
    Division of Microbial Diseases UCL Eastman Dental Institute University College London 256 Grays Inn Road London WC1X 8LD UK
  • Charlotte K. Williams
    Department of Chemistry Imperial College London London SW7 2AZ UK
  • Milo S. P. Shaffer
    Department of Chemistry Imperial College London London SW7 2AZ UK
  • Ivan P. Parkin
    Materials Chemistry Research Centre Department of Chemistry University College London 20 Gordon St London WC1H 0AJ UK

説明

<jats:p>The prevalence of healthcare‐associated infection caused by multidrug‐resistant bacteria is of critical concern worldwide. It is reported on the development of a bactericidal surface prepared by use of a simple, upscalable, two‐step dipping strategy to incorporate crystal violet and di(octyl)­phosphinic‐ acid‐capped zinc oxide nanoparticles into medical grade silicone, as a strategy to reduce the risk of infection. The material is characterized by UV–vis absorbance spectroscopy, X‐ray photoelectron spectroscopy (XPS), inductively coupled plasma‐optical emission spectroscopy (ICP‐OES) and transmission electron microscopy (TEM) and confirmed the incorporation of the ZnO nanoparticles in the polymer. The novel system proves to be a highly versatile bactericidal material when tested against both <jats:italic>Staphylococcus aureus</jats:italic> and <jats:italic>Escherichia coli</jats:italic>, key causative micro‐organisms for hospital‐acquired infection (HAI). Potent antimicrobial activity is noted under dark conditions, with a significant enhancement exhibits when the surfaces are illuminated with a standard hospital light source. This polymer has the potential to decrease the risk of HAI, by killing bacteria in contact with the surface.</jats:p>

収録刊行物

被引用文献 (1)*注記

もっと見る

問題の指摘

ページトップへ