Heterocyclic Diamidine DNA Ligands as HOXA9 Transcription Factor Inhibitors: Design, Molecular Evaluation, and Cellular Consequences in a HOXA9-Dependant Leukemia Cell Model

  • Sabine Depauw
    UMR-S1172-JPARC (Jean-Pierre Aubert Research Center), INSERM, University of Lille, Centre Hospitalier Universitaire de Lille, Institut pour la Recherche sur le Cancer de Lille (IRCL), F-59045 Lille, France
  • Mélanie Lambert
    UMR-S1172-JPARC (Jean-Pierre Aubert Research Center), INSERM, University of Lille, Centre Hospitalier Universitaire de Lille, Institut pour la Recherche sur le Cancer de Lille (IRCL), F-59045 Lille, France
  • Samy Jambon
    UMR-S1172-JPARC (Jean-Pierre Aubert Research Center), INSERM, University of Lille, Centre Hospitalier Universitaire de Lille, Institut pour la Recherche sur le Cancer de Lille (IRCL), F-59045 Lille, France
  • Ananya Paul
    Department of Chemistry, Georgia State University, Atlanta, Georgia 30303, United States
  • Paul Peixoto
    UMR-S1172-JPARC (Jean-Pierre Aubert Research Center), INSERM, University of Lille, Centre Hospitalier Universitaire de Lille, Institut pour la Recherche sur le Cancer de Lille (IRCL), F-59045 Lille, France
  • Raja Nhili
    UMR-S1172-JPARC (Jean-Pierre Aubert Research Center), INSERM, University of Lille, Centre Hospitalier Universitaire de Lille, Institut pour la Recherche sur le Cancer de Lille (IRCL), F-59045 Lille, France
  • Laura Marongiu
    UMR-S1172-JPARC (Jean-Pierre Aubert Research Center), INSERM, University of Lille, Centre Hospitalier Universitaire de Lille, Institut pour la Recherche sur le Cancer de Lille (IRCL), F-59045 Lille, France
  • Martin Figeac
    Functional and Structural Genomic Platform, Lille University, F-59000 Lille, France
  • Christelle Dassi
    UMR-S1172-JPARC (Jean-Pierre Aubert Research Center), INSERM, University of Lille, Centre Hospitalier Universitaire de Lille, Institut pour la Recherche sur le Cancer de Lille (IRCL), F-59045 Lille, France
  • Charles Paul-Constant
    UMR-S1172-JPARC (Jean-Pierre Aubert Research Center), INSERM, University of Lille, Centre Hospitalier Universitaire de Lille, Institut pour la Recherche sur le Cancer de Lille (IRCL), F-59045 Lille, France
  • Benjamin Billoré
    UMR-S1172-JPARC (Jean-Pierre Aubert Research Center), INSERM, University of Lille, Centre Hospitalier Universitaire de Lille, Institut pour la Recherche sur le Cancer de Lille (IRCL), F-59045 Lille, France
  • Arvind Kumar
    Department of Chemistry, Georgia State University, Atlanta, Georgia 30303, United States
  • Abdelbasset A. Farahat
    Department of Chemistry, Georgia State University, Atlanta, Georgia 30303, United States
  • Mohamed A. Ismail
    Department of Chemistry, Georgia State University, Atlanta, Georgia 30303, United States
  • Ekaterina Mineva
    Department of Chemistry, Georgia State University, Atlanta, Georgia 30303, United States
  • Daniel P. Sweat
    Department of Chemistry and Physics, Augusta University, Augusta, Georgia 30904, United States
  • Chad E. Stephens
    Department of Chemistry and Physics, Augusta University, Augusta, Georgia 30904, United States
  • David W. Boykin
    Department of Chemistry, Georgia State University, Atlanta, Georgia 30303, United States
  • W. David Wilson
    Department of Chemistry, Georgia State University, Atlanta, Georgia 30303, United States
  • Marie-Hélène David-Cordonnier
    UMR-S1172-JPARC (Jean-Pierre Aubert Research Center), INSERM, University of Lille, Centre Hospitalier Universitaire de Lille, Institut pour la Recherche sur le Cancer de Lille (IRCL), F-59045 Lille, France

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