Landscape of innate lymphoid cells in human head and neck cancer reveals divergent NK cell states in the tumor microenvironment
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- Uriel Y. Moreno-Nieves
- Department of Otolaryngology—Head and Neck Surgery, Stanford Cancer Institute, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305;
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- Joshua K. Tay
- Department of Otolaryngology—Head and Neck Surgery, Stanford Cancer Institute, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305;
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- Saumyaa Saumyaa
- Department of Otolaryngology—Head and Neck Surgery, Stanford Cancer Institute, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305;
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- Nina B. Horowitz
- Department of Otolaryngology—Head and Neck Surgery, Stanford Cancer Institute, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305;
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- June Ho Shin
- Department of Otolaryngology—Head and Neck Surgery, Stanford Cancer Institute, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305;
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- Imran A. Mohammad
- Department of Otolaryngology—Head and Neck Surgery, Stanford Cancer Institute, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305;
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- Bogdan Luca
- Department of Biomedical Data Science, Stanford Cancer Institute, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305;
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- David C. Mundy
- Department of Otolaryngology—Head and Neck Surgery, Stanford Cancer Institute, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305;
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- Gunsagar S. Gulati
- Department of Biomedical Data Science, Stanford Cancer Institute, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305;
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- Nikita Bedi
- Department of Otolaryngology—Head and Neck Surgery, Stanford Cancer Institute, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305;
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- Serena Chang
- Department of Otolaryngology—Head and Neck Surgery, Stanford Cancer Institute, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305;
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- Chen Chen
- Department of Otolaryngology—Head and Neck Surgery, Stanford Cancer Institute, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305;
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- Michael J. Kaplan
- Department of Otolaryngology—Head and Neck Surgery, Stanford Cancer Institute, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305;
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- Eben L. Rosenthal
- Department of Otolaryngology—Head and Neck Surgery, Stanford Cancer Institute, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305;
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- F. Christopher Holsinger
- Department of Otolaryngology—Head and Neck Surgery, Stanford Cancer Institute, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305;
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- Vasu Divi
- Department of Otolaryngology—Head and Neck Surgery, Stanford Cancer Institute, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305;
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- Fred M. Baik
- Department of Otolaryngology—Head and Neck Surgery, Stanford Cancer Institute, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305;
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- Davud B. Sirjani
- Department of Otolaryngology—Head and Neck Surgery, Stanford Cancer Institute, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305;
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- Andrew J. Gentles
- Department of Biomedical Data Science, Stanford Cancer Institute, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305;
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- Aaron M. Newman
- Department of Biomedical Data Science, Stanford Cancer Institute, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305;
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- Aharon G. Freud
- Department of Pathology, The James Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210
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- John B. Sunwoo
- Department of Otolaryngology—Head and Neck Surgery, Stanford Cancer Institute, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305;
抄録
<jats:title>Significance</jats:title> <jats:p>NK cells have been observed to be present within most solid tumors, but the antitumor activity of the intratumoral NK cells has been unclear. In this study, we examined the entire spectrum of innate lymphoid cells within primary human tumors and demonstrate that peripheral NK cells in the tumor microenvironment differentiate into heterogeneous cell states, resulting in either a hyporesponsive NK cell subset or a highly active NK cell phenotype that closely resembles intraepithelial ILC1s and that has potent antitumor properties. Importantly, this differentiation into ieILC1-like cells occurs when NK cells are cocultured with epithelial cells, providing important information for NK cell immunotherapy approaches.</jats:p>
収録刊行物
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- Proceedings of the National Academy of Sciences
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Proceedings of the National Academy of Sciences 118 (28), 2021-07-09
Proceedings of the National Academy of Sciences