-
- Silvia Domcke
- Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.
-
- Andrew J. Hill
- Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.
-
- Riza M. Daza
- Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.
-
- Junyue Cao
- Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.
-
- Diana R. O’Day
- Department of Pediatrics, University of Washington School of Medicine, Seattle, WA, USA.
-
- Hannah A. Pliner
- Brotman Baty Institute for Precision Medicine, Seattle, WA, USA.
-
- Kimberly A. Aldinger
- Department of Pediatrics, University of Washington School of Medicine, Seattle, WA, USA.
-
- Dmitry Pokholok
- Illumina, San Diego, CA, USA.
-
- Fan Zhang
- Illumina, San Diego, CA, USA.
-
- Jennifer H. Milbank
- Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.
-
- Michael A. Zager
- Brotman Baty Institute for Precision Medicine, Seattle, WA, USA.
-
- Ian A. Glass
- Department of Pediatrics, University of Washington School of Medicine, Seattle, WA, USA.
-
- Frank J. Steemers
- Illumina, San Diego, CA, USA.
-
- Dan Doherty
- Department of Pediatrics, University of Washington School of Medicine, Seattle, WA, USA.
-
- Cole Trapnell
- Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.
-
- Darren A. Cusanovich
- Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.
-
- Jay Shendure
- Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.
説明
<jats:title>The genomics of human development</jats:title> <jats:p> Understanding the trajectory of a developing human requires an understanding of how genes are regulated and expressed. Two papers now present a pooled approach using three levels of combinatorial indexing to examine the single-cell gene expression and chromatin landscapes from 15 organs in fetal samples. Cao <jats:italic>et al.</jats:italic> focus on measurements of RNA in broadly distributed cell types and provide insights into organ specificity. Domcke <jats:italic>et al.</jats:italic> examined the chromatin accessibility of cells from these organs and identify the regulatory elements that regulate gene expression. Together, these analyses generate comprehensive atlases of early human development. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aba7721">eaba7721</jats:related-article> , p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aba7612">eaba7612</jats:related-article> </jats:p>
収録刊行物
-
- Science
-
Science 370 (6518), 2020-11-13
American Association for the Advancement of Science (AAAS)