Medication-Naïve Blood Pressure and Incident Cancers: Analysis of 2 Nationwide Population-Based Databases
-
- Hidehiro Kaneko
- Department of Cardiovascular Medicine, The University of Tokyo , Tokyo , Japan
-
- Yuichiro Yano
- YCU Center for Novel and Exploratory Clinical Trials, Yokohama City University Hospital , Yokohama , Japan
-
- Hyeok-Hee Lee
- Department of Preventive Medicine, Yonsei University College of Medicine , Seoul , Korea
-
- Hokyou Lee
- Department of Preventive Medicine, Yonsei University College of Medicine , Seoul , Korea
-
- Akira Okada
- Department of Prevention of Diabetes and Lifestyle-Related Diseases, Graduate School of Medicine, The University of Tokyo , Tokyo , Japan
-
- Hidetaka Itoh
- Department of Cardiovascular Medicine, The University of Tokyo , Tokyo , Japan
-
- Kojiro Morita
- Global Nursing Research Center, Graduate School of Medicine, The University of Tokyo , Tokyo , Japan
-
- Akira Fukui
- Division of Nephrology and Hypertension, Department of Internal Medicine, Jikei University School of Medicine , Tokyo , Japan
-
- Katsuhito Fujiu
- Department of Cardiovascular Medicine, The University of Tokyo , Tokyo , Japan
-
- Yuta Suzuki
- Department of Cardiovascular Medicine, The University of Tokyo , Tokyo , Japan
-
- Satoshi Matsuoka
- Department of Cardiovascular Medicine, The University of Tokyo , Tokyo , Japan
-
- Sunao Nakamura
- Department of Cardiology, New Tokyo Hospital , Matsudo , Japan
-
- Nobuaki Michihata
- Department of Health Services Research, The University of Tokyo , Tokyo , Japan
-
- Taisuke Jo
- Department of Health Services Research, The University of Tokyo , Tokyo , Japan
-
- Norifumi Takeda
- Department of Cardiovascular Medicine, The University of Tokyo , Tokyo , Japan
-
- Hiroyuki Morita
- Department of Cardiovascular Medicine, The University of Tokyo , Tokyo , Japan
-
- Takashi Yokoo
- Division of Nephrology and Hypertension, Department of Internal Medicine, Jikei University School of Medicine , Tokyo , Japan
-
- Akira Nishiyama
- Department of Pharmacology, Faculty of Medicine, Kagawa University , Kagawa , Japan
-
- Koichi Node
- Department of Cardiovascular Medicine, Saga University , Saga , Japan
-
- Anthony J Viera
- Department of Family Medicine and Community Health, Duke University , Durham, North Carolina , USA
-
- Paul Muntner
- Department of Epidemiology, University of Alabama at Birmingham , Birmingham, Alabama , USA
-
- Suzanne Oparil
- Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham , Birmingham, Alabama , USA
-
- Hyeon Chang Kim
- Department of Preventive Medicine, Yonsei University College of Medicine , Seoul , Korea
-
- Hideo Yasunaga
- Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo , Tokyo , Japan
-
- Issei Komuro
- Department of Cardiovascular Medicine, The University of Tokyo , Tokyo , Japan
抄録
<jats:title>Abstract</jats:title> <jats:sec> <jats:title>BACKGROUND</jats:title> <jats:p>Results of preceding studies on the relationship between blood pressure (BP) and cancers have been confounded due to individuals taking antihypertensive medications or shared risk factors. We assessed whether medication-naïve high BP is a risk factor for incident cancers.</jats:p> </jats:sec> <jats:sec> <jats:title>METHODS</jats:title> <jats:p>This retrospective observational study included 1,388,331 individuals without a prior history of cancer and not taking antihypertensive medications enrolled in the JMDC Claims Database between 2005 and 2018. The primary outcome was 16 cancers.</jats:p> </jats:sec> <jats:sec> <jats:title>RESULTS</jats:title> <jats:p>The median [interquartile range] age was 45 [40–52] years and 56.2% were men. Mean systolic BP (SBP) and diastolic BP (DBP) were 117.7 ± 15.8 and 72.8 ± 11.6 mm Hg. Multivariate Cox regression analysis demonstrated that SBP per 1-SD was associated with a higher incidence of thyroid (hazard ratio [HR]: 1.09, 95% confidence interval [CI]: 1.03–1.16), esophageal (HR: 1.15, 95% CI: 1.07–1.24), colorectal (HR: 1.04, 95% CI: 1.01–1.07), liver (HR: 1.11, 95% CI: 1.03–1.20), and kidney (HR: 1.22, 95% CI: 1.14–1.31) cancers, but with a lower incidence of stomach cancer (HR: 0.94, 95% CI: 0.91–0.98). These associations remained significant after adjustment for multiple testing. DBP was associated with higher incidences of thyroid, esophageal, colorectal, kidney, and corpus uteri cancers, but with a lower incidence of stomach cancer. The associations between SBP and incidences of thyroid, esophageal, colorectal, liver, and kidney cancers were confirmed in the Korean National Health Insurance Service database.</jats:p> </jats:sec> <jats:sec> <jats:title>CONCLUSIONS</jats:title> <jats:p>Medication-naïve BP was associated with higher incidences of thyroid, esophageal, colorectal, liver, and kidney cancers. Uncovering the underlying mechanisms for our results may help identify novel therapeutic approach for hypertension and cancer.</jats:p> </jats:sec>
収録刊行物
-
- American Journal of Hypertension
-
American Journal of Hypertension 35 (8), 731-739, 2022-05-04
Oxford University Press (OUP)