-
- Young-Jun Park
- Department of Biochemistry, University of Washington, Seattle, WA, USA.
-
- Dora Pinto
- Humabs Biomed SA, Subsidiary of Vir Biotechnology, Bellinzona, Switzerland.
-
- Alexandra C. Walls
- Department of Biochemistry, University of Washington, Seattle, WA, USA.
-
- Zhuoming Liu
- Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA.
-
- Anna De Marco
- Humabs Biomed SA, Subsidiary of Vir Biotechnology, Bellinzona, Switzerland.
-
- Fabio Benigni
- Humabs Biomed SA, Subsidiary of Vir Biotechnology, Bellinzona, Switzerland.
-
- Fabrizia Zatta
- Humabs Biomed SA, Subsidiary of Vir Biotechnology, Bellinzona, Switzerland.
-
- Chiara Silacci-Fregni
- Humabs Biomed SA, Subsidiary of Vir Biotechnology, Bellinzona, Switzerland.
-
- Jessica Bassi
- Humabs Biomed SA, Subsidiary of Vir Biotechnology, Bellinzona, Switzerland.
-
- Kaitlin R. Sprouse
- Department of Biochemistry, University of Washington, Seattle, WA, USA.
-
- Amin Addetia
- Department of Biochemistry, University of Washington, Seattle, WA, USA.
-
- John E. Bowen
- Department of Biochemistry, University of Washington, Seattle, WA, USA.
-
- Cameron Stewart
- Department of Biochemistry, University of Washington, Seattle, WA, USA.
-
- Martina Giurdanella
- Humabs Biomed SA, Subsidiary of Vir Biotechnology, Bellinzona, Switzerland.
-
- Christian Saliba
- Humabs Biomed SA, Subsidiary of Vir Biotechnology, Bellinzona, Switzerland.
-
- Barbara Guarino
- Humabs Biomed SA, Subsidiary of Vir Biotechnology, Bellinzona, Switzerland.
-
- Michael A. Schmid
- Humabs Biomed SA, Subsidiary of Vir Biotechnology, Bellinzona, Switzerland.
-
- Nicholas M. Franko
- Division of Allergy and Infectious Diseases, University of Washington, Seattle, WA, USA.
-
- Jennifer K. Logue
- Division of Allergy and Infectious Diseases, University of Washington, Seattle, WA, USA.
-
- Ha V. Dang
- Vir Biotechnology, San Francisco, CA, USA.
-
- Kevin Hauser
- Vir Biotechnology, San Francisco, CA, USA.
-
- Julia di Iulio
- Vir Biotechnology, San Francisco, CA, USA.
-
- William Rivera
- Vir Biotechnology, San Francisco, CA, USA.
-
- Gretja Schnell
- Vir Biotechnology, San Francisco, CA, USA.
-
- Anushka Rajesh
- Vir Biotechnology, San Francisco, CA, USA.
-
- Jiayi Zhou
- Vir Biotechnology, San Francisco, CA, USA.
-
- Nisar Farhat
- Vir Biotechnology, San Francisco, CA, USA.
-
- Hannah Kaiser
- Vir Biotechnology, San Francisco, CA, USA.
-
- Martin Montiel-Ruiz
- Vir Biotechnology, San Francisco, CA, USA.
-
- Julia Noack
- Vir Biotechnology, San Francisco, CA, USA.
-
- Florian A. Lempp
- Vir Biotechnology, San Francisco, CA, USA.
-
- Javier Janer
- Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA.
-
- Rana Abdelnabi
- KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, B-3000 Leuven, Belgium.
-
- Piet Maes
- KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, B-3000 Leuven, Belgium.
-
- Paolo Ferrari
- Faculty of Biomedical Sciences, Università della Svizzera italiana, Lugano, Switzerland.
-
- Alessandro Ceschi
- Faculty of Biomedical Sciences, Università della Svizzera italiana, Lugano, Switzerland.
-
- Olivier Giannini
- Faculty of Biomedical Sciences, Università della Svizzera italiana, Lugano, Switzerland.
-
- Guilherme Dias de Melo
- Institut Pasteur, Université Paris Cité, Lyssavirus Epidemiology and Neuropathology Unit, F-75015 Paris, France.
-
- Lauriane Kergoat
- Institut Pasteur, Université Paris Cité, Lyssavirus Epidemiology and Neuropathology Unit, F-75015 Paris, France.
-
- Hervé Bourhy
- Institut Pasteur, Université Paris Cité, Lyssavirus Epidemiology and Neuropathology Unit, F-75015 Paris, France.
-
- Johan Neyts
- KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, B-3000 Leuven, Belgium.
-
- Leah Soriaga
- Vir Biotechnology, San Francisco, CA, USA.
-
- Lisa A. Purcell
- Vir Biotechnology, San Francisco, CA, USA.
-
- Gyorgy Snell
- Vir Biotechnology, San Francisco, CA, USA.
-
- Sean P.J. Whelan
- Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA.
-
- Antonio Lanzavecchia
- Humabs Biomed SA, Subsidiary of Vir Biotechnology, Bellinzona, Switzerland.
-
- Herbert W. Virgin
- Vir Biotechnology, San Francisco, CA, USA.
-
- Luca Piccoli
- Humabs Biomed SA, Subsidiary of Vir Biotechnology, Bellinzona, Switzerland.
-
- Helen Y. Chu
- Division of Allergy and Infectious Diseases, University of Washington, Seattle, WA, USA.
-
- Matteo Samuele Pizzuto
- Humabs Biomed SA, Subsidiary of Vir Biotechnology, Bellinzona, Switzerland.
-
- Davide Corti
- Humabs Biomed SA, Subsidiary of Vir Biotechnology, Bellinzona, Switzerland.
-
- David Veesler
- Department of Biochemistry, University of Washington, Seattle, WA, USA.
説明
<jats:p>Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron sublineages carry distinct spike mutations resulting in escape from antibodies induced by previous infection or vaccination. We show that hybrid immunity or vaccine boosters elicit plasma-neutralizing antibodies against Omicron BA.1, BA.2, BA.2.12.1, and BA.4/5, and that breakthrough infections, but not vaccination alone, induce neutralizing antibodies in the nasal mucosa. Consistent with immunological imprinting, most antibodies derived from memory B cells or plasma cells of Omicron breakthrough cases cross-react with the Wuhan-Hu-1, BA.1, BA.2, and BA.4/5 receptor-binding domains, whereas Omicron primary infections elicit B cells of narrow specificity up to 6 months after infection. Although most clinical antibodies have reduced neutralization of Omicron, we identified an ultrapotent pan-variant–neutralizing antibody that is a strong candidate for clinical development.</jats:p>
収録刊行物
-
- Science
-
Science 378 (6620), 619-627, 2022-11-11
American Association for the Advancement of Science (AAAS)
