Bioactive Scalarane‐Type Sesterterpenoids from Marine Sources

  • Hao‐Bing Yu
    Department of Marine Biomedicine and Polar Medicine Naval Medical Center of PLA Naval Medical University Xiangyin Road 800 Shanghai 200433 P. R. China
  • Hai‐Yan Chen
    Department of Endocrinology Changzheng Hospital Naval Medical University Shanghai 200003 P. R. China
  • Song Duan
    Department of Marine Biomedicine and Polar Medicine Naval Medical Center of PLA Naval Medical University Xiangyin Road 800 Shanghai 200433 P. R. China
  • Yu‐Ping Zhu
    College of Basic Medical Sciences Experimental Teaching Center Naval Medical University Shanghai 200433 China
  • Bo Hu
    Department of Marine Biomedicine and Polar Medicine Naval Medical Center of PLA Naval Medical University Xiangyin Road 800 Shanghai 200433 P. R. China
  • Ying He
    Department of Marine Biomedicine and Polar Medicine Naval Medical Center of PLA Naval Medical University Xiangyin Road 800 Shanghai 200433 P. R. China
  • Si‐Tong Cheng
    WLSA Shanghai Academy Shanghai 2004333 P. R. China
  • Bing‐Hua Jiao
    Department of Marine Biomedicine and Polar Medicine Naval Medical Center of PLA Naval Medical University Xiangyin Road 800 Shanghai 200433 P. R. China
  • Xiao‐Yu Liu
    Department of Marine Biomedicine and Polar Medicine Naval Medical Center of PLA Naval Medical University Xiangyin Road 800 Shanghai 200433 P. R. China

抄録

<jats:title>Abstract</jats:title><jats:p>Scalarane‐type sesterterpenoids have received considerable attention in the scientific literature due to their diverse carbon skeletons and various biological activities and pharmacological properties. Among all these derivatives are commonly isolated from marine sponges and are occasionally derived from shell‐less mollusks, such as nudibranchs. This review comprehensively discusses the marine‐derived natural sources that give rise to these scalarane‐type sesterterpenoids, providing the names, their chemical structures, biological properties, with emphasis on anticancer activity and literature references related to these metabolites. A critical summary of the 221 compounds generated from January 2010 up to December 2021 for their potential as anticancer agents is presented.</jats:p>

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