In situ optical spectroscopy of crystallization: One crystal nucleation at a time
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- Oscar Urquidi
- Department of Physical Chemistry, Sciences II, University of Geneva, 1211 Geneva, Switzerland
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- Johanna Brazard
- Department of Physical Chemistry, Sciences II, University of Geneva, 1211 Geneva, Switzerland
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- Natalie LeMessurier
- Department of Chemistry, McGill University, Montreal, QC H3A 0B8, Canada
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- Lena Simine
- Department of Chemistry, McGill University, Montreal, QC H3A 0B8, Canada
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- Takuji B. M. Adachi
- Department of Physical Chemistry, Sciences II, University of Geneva, 1211 Geneva, Switzerland
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説明
<jats:title>Significance</jats:title><jats:p>It is of fundamental importance to establish the microscopic picture of crystal nucleation for both academic and industrial research. Here, we report an in situ time-resolved Raman spectroscopy to study crystallization from solution, one crystal nucleation at a time. The observed dynamics of α-glycine crystallization from water without any additive supports the nonclassical nucleation pathway, where prenucleation aggregates form and convert to a crystal. By the direct comparison of Raman spectrum of the aggregates between the experiment and simulation, we propose the structure of these aggregates as linear hydrogen-bonded networks. We demonstrate the power of studying one nucleation event at a time, which can accelerate the investigation of crystal nucleation by optical spectroscopy.</jats:p>
収録刊行物
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- Proceedings of the National Academy of Sciences
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Proceedings of the National Academy of Sciences 119 (16), 2022-04-08
Proceedings of the National Academy of Sciences
