Evaluation of the Antimicrobial and Antivirulent Potential of Essential Oils Isolated from Juniperus oxycedrus L. ssp. macrocarpa Aerial Parts
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- Gabriella Spengler
- Department of Medical Microbiology, Albert Szent-Györgyi Health Center and Albert Szent-Györgyi Medical School, University of Szeged, Semmelweis Utca 6, 6725 Szeged, Hungary
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- Márió Gajdács
- Department of Oral Biology and Experimental Dental Research, Faculty of Dentistry, University of Szeged, Tisza Lajos krt. 63, 6720 Szeged, Hungary
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- Matthew Gavino Donadu
- Hospital Pharmacy, Azienda Ospedaliero Universitaria di Sassari, 07100 Sassari, Italy
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- Marianna Usai
- Department of Chemistry and Pharmacy, University of Sassari, 07100 Sassari, Italy
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- Mauro Marchetti
- Institute of Biomolecular Chemistry (CNR), Li Punti, 07100 Sassari, Italy
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- Marco Ferrari
- Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy
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- Vittorio Mazzarello
- Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy
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- Stefania Zanetti
- Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy
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- Fruzsina Nagy
- Department of Medical Microbiology, Faculty of Medicine and Pharmacy, University of Debrecen, Nagyerdei krt. 98, 4032 Debrecen, Hungary
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- Renátó Kovács
- Department of Medical Microbiology, Faculty of Medicine and Pharmacy, University of Debrecen, Nagyerdei krt. 98, 4032 Debrecen, Hungary
説明
<jats:p>As a consequence of the worsening situation with multidrug-resistant (MDR) pathogens and a disparity in the commercialization of novel antimicrobial agents, scientists have been prompted to seek out new compounds with antimicrobial activity from a wide range of sources, including medicinal plants. In the present study, the antibacterial, antifungal, anti-virulence, and resistance-modulating properties of the essential oil from the Sardinian endemic Juniperus oxycedrus L. ssp. macrocarpa aerial parts were evaluated. The GC/MS analysis showed that the main compounds in the oil were α-pinene (56.63 ± 0.24%), limonene (14.66 ± 0.11%), and β-pinene (13.42 ± 0.09%). The essential oil showed potent antibacterial activity against Gram-positive bacteria (0.25–2 v/v%) and Salmonella spp. (4 v/v%). The strongest fungicidal activity was recorded against Candida auris sessile cells (median FICI was 0.088) but not against C. albicans biofilms (median FICI was 1). The oil showed potent efflux pump inhibitory properties in the case of Staphylococcus aureus and Escherichia coli. The therapeutic potential of Juniperus may be promising for future more extensive research and in vivo tests to develop new drugs against antibiotic and antifungal resistance.</jats:p>
収録刊行物
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- Microorganisms
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Microorganisms 10 (4), 758-, 2022-03-31
MDPI AG