ICAM-1 induced rearrangements of capsid and genome prime rhinovirus 14 for activation and uncoating
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- Dominik Hrebík
- Central European Institute of Technology, Masaryk University, Brno 62500, Czech Republic
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- Tibor Füzik
- Central European Institute of Technology, Masaryk University, Brno 62500, Czech Republic
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- Mária Gondová
- Central European Institute of Technology, Masaryk University, Brno 62500, Czech Republic
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- Lenka Šmerdová
- Central European Institute of Technology, Masaryk University, Brno 62500, Czech Republic
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- Athanassios Adamopoulos
- Central European Institute of Technology, Masaryk University, Brno 62500, Czech Republic
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- Ondrej Šedo
- Central European Institute of Technology, Masaryk University, Brno 62500, Czech Republic
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- Zbyněk Zdráhal
- Central European Institute of Technology, Masaryk University, Brno 62500, Czech Republic
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- Pavel Plevka
- Central European Institute of Technology, Masaryk University, Brno 62500, Czech Republic
抄録
<jats:title>Significance</jats:title><jats:p>Medical visits and missed days of school and work caused by rhinoviruses cost tens of billions of US dollars annually. Currently, there are no antivirals against rhinoviruses, and the available treatments only treat the symptoms. Here, we present the molecular structure of human rhinovirus 14 in complex with its cellular receptor intercellular adhesion molecule 1. The binding of the virus to its receptor initiates the infection. Knowledge of the structure of the human rhinovirus 14–intercellular adhesion molecule 1 interface and mechanism of interaction provides the basis for the design of compounds that may block the binding of rhinoviruses to receptors and thus prevent infection.</jats:p>
収録刊行物
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- Proceedings of the National Academy of Sciences
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Proceedings of the National Academy of Sciences 118 (19), 2021-05-05
Proceedings of the National Academy of Sciences