-
- Elias Rawish
- Cardioimmunology Group, Medical Clinic II University Heart Center Lübeck Lübeck Germany
-
- Manuela Sauter
- Cardioimmunology Group, Medical Clinic II University Heart Center Lübeck Lübeck Germany
-
- Reinhard Sauter
- Cardioimmunology Group, Medical Clinic II University Heart Center Lübeck Lübeck Germany
-
- Henry Nording
- Cardioimmunology Group, Medical Clinic II University Heart Center Lübeck Lübeck Germany
-
- Harald F. Langer
- Cardioimmunology Group, Medical Clinic II University Heart Center Lübeck Lübeck Germany
説明
<jats:sec><jats:label /><jats:p>A mutual relationship exists between immune activation and mechanisms of thrombus formation. In particular, elements of the innate immune response such as the complement system can modulate platelet activation and subsequently thrombus formation. Several components of the complement system including C3 or the membrane attack complex have been reported to be associated with platelets and become functionally active in the micromilieu of platelet activation. The exact mechanisms how this interplay is regulated and its consequences for tissue inflammation, damage or recovery remain to be defined. This review addresses the current state of knowledge on this topic and puts it into context with diseases featuring both thrombosis and complement activation.</jats:p></jats:sec><jats:sec><jats:title>Linked Articles</jats:title><jats:p>This article is part of a themed issue on Canonical and non‐canonical functions of the complement system in health and disease. To view the other articles in this section visit <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="http://onlinelibrary.wiley.com/doi/10.1111/bph.v178.14/issuetoc">http://onlinelibrary.wiley.com/doi/10.1111/bph.v178.14/issuetoc</jats:ext-link></jats:p></jats:sec>
収録刊行物
-
- British Journal of Pharmacology
-
British Journal of Pharmacology 178 (14), 2892-2904, 2021-05-30
Wiley