Clinical reporting following the quantification of cerebrospinal fluid biomarkers in Alzheimer's disease: An international overview
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- Constance Delaby
- LBPC‐PPC Univ Montpellier CHU Montpellier INSERM Montpellier France
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- Charlotte E. Teunissen
- Neurochemistry Lab Department of Clinical Chemistry Amsterdam Neuroscience Amsterdam UMC Vrije Universiteit Amsterdam Amsterdam Netherlands
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- Kaj Blennow
- Institute of Neuroscience and Physiology The Sahlgrenska Academy at the University of Gothenburg Gothenburg Sweden
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- Daniel Alcolea
- Hospital de la Santa Creu i Sant Pau ‐ Biomedical Research Institute Sant Pau ‐ Universitat Autònoma de Barcelona Barcelona Spain
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- Ivan Arisi
- European Brain Research Institute (EBRI) “Rita Levi‐Montalcini” Roma Italy
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- Elodie Bouaziz Amar
- Université de Paris Cognitive Neurology Center GHU APHP Nord Lariboisière Fernand‐Widal Hospital Paris France
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- Anne Beaume
- CHU Poitiers Poitiers France
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- Aurélie Bedel
- CHU Bordeaux Bordeaux France
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- Giovanni Bellomo
- Lab of Clinical Neurochemistry Section of Neurology Dept. of Medicine and Surgery University of Perugia Perugia Italy
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- Edith Bigot‐Corbel
- Laboratoire de Biochimie Hôpital G & R Laënnec CHU de Nantes Nantes France
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- Maria Bjerke
- Vrije Universiteit Brussel Center for Neurosciences and Department of Clinical Biology Clinical Neurochemistry Laboratory Universitair Ziekenhuis Brussel Brussels Belgium
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- Marie‐Céline Blanc‐Quintin
- APHP Centre—Université de Paris, Cochin Hospital Paris France
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- Mercè Boada
- Research Center and Memory Clinic Fundació ACE Institut Català de Neurociències Aplicades and Universitat Internacional de Catalunya (UIC) Barcelona Spain
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- Olivier Bousiges
- Laboratoire de Biochimie et Biologie Moléculaire, et CNRS ICube Laboratory UMR 7357 and FMTS (Fédération de Médecine Translationnelle de Strasbourg) Team IMIS Hôpitaux Universitaires de Strasbourg Strasbourg France
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- Miles D Chapman
- Department of Neuroimmunology National Hospital for Neurology and Neurosurgery, UCL Queen Square London UK
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- Mari L. DeMarco
- Department of Pathology and Laboratory Medicine St. Paul's Hospital, Providence Health Care, Vancouver, Canada & Department of Pathology & Laboratory Medicine University of British Columbia Vancouver Canada
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- Mara D'Onofrio
- European Brain Research Institute (EBRI) “Rita Levi‐Montalcini” Roma Italy
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- Julien Dumurgier
- Université de Paris Cognitive Neurology Center GHU APHP Nord Lariboisière Fernand‐Widal Hospital Paris France
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- Diane Dufour‐Rainfray
- CHU Tours UMR 1253‐ iBrain Tours France
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- Sebastiaan Engelborghs
- Department of Biomedical Sciences, Institute Born‐Bunge University of Antwerp Antwerp Belgium
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- Hermann Esselmann
- Department of Psychiatry and Psychotherapy University Medical Center Goettingen (UMG Goettingen Germany
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- Anne Fogli
- CHU Clermont‐Ferrand Clermont‐Ferrand France
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- Audrey Gabelle
- LBPC‐PPC Univ Montpellier CHU Montpellier INSERM Montpellier France
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- Elisabetta Galloni
- Dipartimento di Neuroscienze Divisione di Neurologia Vicenza Italy
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- Clémentine Gondolf
- CHU Cote de Nacre Caen Caen France
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- Frédérique Grandhomme
- CHU Cote de Nacre Caen Caen France
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- Oriol Grau‐Rivera
- Barcelonaβeta Brain Research Center (BBRC) Pasqual Maragall Foundation Barcelona Spain
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- Melanie Hart
- Department of Neuroimmunology National Hospital for Neurology and Neurosurgery, UCL Queen Square London UK
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- Takeshi Ikeuchi
- Dept. of Molecular Genetics Center for Bioresources Brain Research Institute Niigata University Niigata Japan
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- Andreas Jeromin
- Cohen Veterans Bioscience Cambridge Massachusetts USA
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- Kensaku Kasuga
- Dept. of Molecular Genetics Center for Bioresources Brain Research Institute Niigata University Niigata Japan
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- Ashvini Keshavan
- Dementia Research Centre UCL Queen Square Institute of Neurology London UK
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- Michael Khalil
- Medical University of Graz Graz Austria
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- Peter Körtvelyessy
- Freie Universität Berlin and Humboldt‐Universität zu Berlin Department of Neurology German Center for Neurodegenerative Diseases, Magdeburg, Germany and Charité‐Universitäts medizin Berlin Berlin Germany
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- Agnieszka Kulczynska‐Przybik
- Department of Neurodegeneration Diagnostics Medical University of Bialystok Bialystok Poland
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- Jean‐Louis Laplanche
- Université de Paris Cognitive Neurology Center GHU APHP Nord Lariboisière Fernand‐Widal Hospital Paris France
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- Piotr Lewczuk
- Department of Neurodegeneration Diagnostics Medical University of Bialystok Bialystok Poland
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- Qiao‐Xin Li
- Florey Institute and The University of Melbourne Melbourne Victoria Australia
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- Alberto Lleó
- Hospital de la Santa Creu i Sant Pau ‐ Biomedical Research Institute Sant Pau ‐ Universitat Autònoma de Barcelona Barcelona Spain
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- Catherine Malaplate
- CHRU de Nancy Laboratoire de Biochimie Biologie Moléculaire et Nutrition/ Université de Lorraine Nancy France
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- Marta Marquié
- Research Center and Memory Clinic Fundació ACE Institut Català de Neurociències Aplicades and Universitat Internacional de Catalunya (UIC) Barcelona Spain
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- Colin L. Masters
- Florey Institute and The University of Melbourne Melbourne Victoria Australia
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- Barbara Mroczko
- Department of Neurodegeneration Diagnostics Medical University of Bialystok Bialystok Poland
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- Léonor Nogueira
- Laboratoire de Biologie Cellulaire et Cytologie CHU PURPAN Toulouse France
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- Adelina Orellana
- Research Center and Memory Clinic Fundació ACE Institut Català de Neurociències Aplicades and Universitat Internacional de Catalunya (UIC) Barcelona Spain
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- Markus Otto
- Department of Neurology and CSF Laboratory University of Ulm Ulm Germany
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- Jean‐Baptiste Oudart
- CNRS UMR 7369, CHU Reims Université de Reims Champagne‐Ardenne Reims France
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- Claire Paquet
- Université de Paris Cognitive Neurology Center GHU APHP Nord Lariboisière Fernand‐Widal Hospital Paris France
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- Federico Paolini Paoletti
- Lab of Clinical Neurochemistry Section of Neurology Dept. of Medicine and Surgery University of Perugia Perugia Italy
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- Lucilla Parnetti
- Lab of Clinical Neurochemistry Section of Neurology Dept. of Medicine and Surgery University of Perugia Perugia Italy
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- Armand Perret‐Liaudet
- Lyon Neuroscience Research Center BIORAN Team ‐ CNRS UMR 5292 INSERM U1028 Lyon University Hospital Lyon France
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- Katell Peoc'h
- Université de Paris GHU APHP Nord Beaujon Hospital Paris France
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- Koen Poesen
- Laboratory for Molecular Neurobiomarker Research (LaMoN) Department of Neurosciences KU Leuven Leuven Brain Institute Leuven Belgium
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- Albert Puig‐Pijoan
- Servei de Neurologia Hospital del Mar Unitat de deteriorament cognitiu i transtorns del moviment Barcelona Spain
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- Isabelle Quadrio
- Lyon Neuroscience Research Center BIORAN Team ‐ CNRS UMR 5292 INSERM U1028 Lyon University Hospital Lyon France
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- Muriel Quillard‐Muraine
- UNIROUEN Rouen University Hospital Department of Clinical biology Biochemistry laboratory Normandie Univ Rouen France
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- Benoit Rucheton
- DMU BioGeM AP‐HP Sorbonne University Paris France
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- Susanna Schraen
- Inserm CHU Lille U1172‐LilNCog LICEND LabEx DISTALZ Université de Lille Lille France
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- Jonathan M. Schott
- Dementia Research Centre UCL Queen Square Institute of Neurology London UK
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- Leslie M. Shaw
- Department of Pathology and Laboratory Medicine Hospital University of Pennsylvania Pennsylvania USA
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- Marc Suárez‐Calvet
- Barcelonaβeta Brain Research Center (BBRC) Pasqual Maragall Foundation Barcelona Spain
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- Magda Tsolaki
- 1st Department of Neurology School of Medicine Faculty of Health of Sciences Aristotle University of Thessaloniki Thessaloniki Greece
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- Hayrettin Tumani
- Department of Neurology and CSF Laboratory University of Ulm Ulm Germany
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- Chinedu T Udeh‐Momoh
- Imperial College London London UK
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- Lucie Vaudran
- CHU Lille Univ. Lille Lille France
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- Marcel M Verbeek
- Donders Institute for Brain, Cognition and Behaviour Radboud Alzheimer Centre Departments of Neurology and Laboratory Medicine Radboud University Medical Center Nijmegen The Netherlands
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- Federico Verde
- Department of Neurology ‐ Stroke Unit and Laboratory of Neuroscience IRCCS Istituto Auxologico Italiano Milan Italy
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- Lisa Vermunt
- Neurochemistry Lab Department of Clinical Chemistry Amsterdam Neuroscience Amsterdam UMC Vrije Universiteit Amsterdam Amsterdam Netherlands
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- Jonathan Vogelgsang
- Department of Psychiatry and Psychotherapy University Medical Center Goettingen (UMG Goettingen Germany
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- Jens Wiltfang
- Department of Psychiatry and Psychotherapy University Medical Center Goettingen (UMG Goettingen Germany
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- Henrik Zetterberg
- Institute of Neuroscience and Physiology The Sahlgrenska Academy at the University of Gothenburg Gothenburg Sweden
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- Sylvain Lehmann
- LBPC‐PPC Univ Montpellier CHU Montpellier INSERM Montpellier France
抄録
<jats:title>Abstract</jats:title><jats:sec><jats:title>Introduction</jats:title><jats:p>The current practice of quantifying cerebrospinal fluid (CSF) biomarkers as an aid in the diagnosis of Alzheimer's disease (AD) varies from center to center. For a same biochemical profile, interpretation and reporting of results may differ, which can lead to misunderstandings and raises questions about the commutability of tests.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>We obtained a description of (pre‐)analytical protocols and sample reports from 40 centers worldwide. A consensus approach allowed us to propose harmonized comments corresponding to the different CSF biomarker profiles observed in patients.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>The (pre‐)analytical procedures were similar between centers. There was considerable heterogeneity in cutoff definitions and report comments. We therefore identified and selected by consensus the most accurate and informative comments regarding the interpretation of CSF biomarkers in the context of AD diagnosis.</jats:p></jats:sec><jats:sec><jats:title>Discussion</jats:title><jats:p>This is the first time that harmonized reports are proposed across worldwide specialized laboratories involved in the biochemical diagnosis of AD.</jats:p></jats:sec>
収録刊行物
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- Alzheimer's & Dementia
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Alzheimer's & Dementia 18 (10), 1868-1879, 2021-12-22
Wiley