Clinical reporting following the quantification of cerebrospinal fluid biomarkers in Alzheimer's disease: An international overview

  • Constance Delaby
    LBPC‐PPC Univ Montpellier CHU Montpellier INSERM Montpellier France
  • Charlotte E. Teunissen
    Neurochemistry Lab Department of Clinical Chemistry Amsterdam Neuroscience Amsterdam UMC Vrije Universiteit Amsterdam Amsterdam Netherlands
  • Kaj Blennow
    Institute of Neuroscience and Physiology The Sahlgrenska Academy at the University of Gothenburg Gothenburg Sweden
  • Daniel Alcolea
    Hospital de la Santa Creu i Sant Pau ‐ Biomedical Research Institute Sant Pau ‐ Universitat Autònoma de Barcelona Barcelona Spain
  • Ivan Arisi
    European Brain Research Institute (EBRI) “Rita Levi‐Montalcini” Roma Italy
  • Elodie Bouaziz Amar
    Université de Paris Cognitive Neurology Center GHU APHP Nord Lariboisière Fernand‐Widal Hospital Paris France
  • Anne Beaume
    CHU Poitiers Poitiers France
  • Aurélie Bedel
    CHU Bordeaux Bordeaux France
  • Giovanni Bellomo
    Lab of Clinical Neurochemistry Section of Neurology Dept. of Medicine and Surgery University of Perugia Perugia Italy
  • Edith Bigot‐Corbel
    Laboratoire de Biochimie Hôpital G & R Laënnec CHU de Nantes Nantes France
  • Maria Bjerke
    Vrije Universiteit Brussel Center for Neurosciences and Department of Clinical Biology Clinical Neurochemistry Laboratory Universitair Ziekenhuis Brussel Brussels Belgium
  • Marie‐Céline Blanc‐Quintin
    APHP Centre—Université de Paris, Cochin Hospital Paris France
  • Mercè Boada
    Research Center and Memory Clinic Fundació ACE Institut Català de Neurociències Aplicades and Universitat Internacional de Catalunya (UIC) Barcelona Spain
  • Olivier Bousiges
    Laboratoire de Biochimie et Biologie Moléculaire, et CNRS ICube Laboratory UMR 7357 and FMTS (Fédération de Médecine Translationnelle de Strasbourg) Team IMIS Hôpitaux Universitaires de Strasbourg Strasbourg France
  • Miles D Chapman
    Department of Neuroimmunology National Hospital for Neurology and Neurosurgery, UCL Queen Square London UK
  • Mari L. DeMarco
    Department of Pathology and Laboratory Medicine St. Paul's Hospital, Providence Health Care, Vancouver, Canada & Department of Pathology & Laboratory Medicine University of British Columbia Vancouver Canada
  • Mara D'Onofrio
    European Brain Research Institute (EBRI) “Rita Levi‐Montalcini” Roma Italy
  • Julien Dumurgier
    Université de Paris Cognitive Neurology Center GHU APHP Nord Lariboisière Fernand‐Widal Hospital Paris France
  • Diane Dufour‐Rainfray
    CHU Tours UMR 1253‐ iBrain Tours France
  • Sebastiaan Engelborghs
    Department of Biomedical Sciences, Institute Born‐Bunge University of Antwerp Antwerp Belgium
  • Hermann Esselmann
    Department of Psychiatry and Psychotherapy University Medical Center Goettingen (UMG Goettingen Germany
  • Anne Fogli
    CHU Clermont‐Ferrand Clermont‐Ferrand France
  • Audrey Gabelle
    LBPC‐PPC Univ Montpellier CHU Montpellier INSERM Montpellier France
  • Elisabetta Galloni
    Dipartimento di Neuroscienze Divisione di Neurologia Vicenza Italy
  • Clémentine Gondolf
    CHU Cote de Nacre Caen Caen France
  • Frédérique Grandhomme
    CHU Cote de Nacre Caen Caen France
  • Oriol Grau‐Rivera
    Barcelonaβeta Brain Research Center (BBRC) Pasqual Maragall Foundation Barcelona Spain
  • Melanie Hart
    Department of Neuroimmunology National Hospital for Neurology and Neurosurgery, UCL Queen Square London UK
  • Takeshi Ikeuchi
    Dept. of Molecular Genetics Center for Bioresources Brain Research Institute Niigata University Niigata Japan
  • Andreas Jeromin
    Cohen Veterans Bioscience Cambridge Massachusetts USA
  • Kensaku Kasuga
    Dept. of Molecular Genetics Center for Bioresources Brain Research Institute Niigata University Niigata Japan
  • Ashvini Keshavan
    Dementia Research Centre UCL Queen Square Institute of Neurology London UK
  • Michael Khalil
    Medical University of Graz Graz Austria
  • Peter Körtvelyessy
    Freie Universität Berlin and Humboldt‐Universität zu Berlin Department of Neurology German Center for Neurodegenerative Diseases, Magdeburg, Germany and Charité‐Universitäts medizin Berlin Berlin Germany
  • Agnieszka Kulczynska‐Przybik
    Department of Neurodegeneration Diagnostics Medical University of Bialystok Bialystok Poland
  • Jean‐Louis Laplanche
    Université de Paris Cognitive Neurology Center GHU APHP Nord Lariboisière Fernand‐Widal Hospital Paris France
  • Piotr Lewczuk
    Department of Neurodegeneration Diagnostics Medical University of Bialystok Bialystok Poland
  • Qiao‐Xin Li
    Florey Institute and The University of Melbourne Melbourne Victoria Australia
  • Alberto Lleó
    Hospital de la Santa Creu i Sant Pau ‐ Biomedical Research Institute Sant Pau ‐ Universitat Autònoma de Barcelona Barcelona Spain
  • Catherine Malaplate
    CHRU de Nancy Laboratoire de Biochimie Biologie Moléculaire et Nutrition/ Université de Lorraine Nancy France
  • Marta Marquié
    Research Center and Memory Clinic Fundació ACE Institut Català de Neurociències Aplicades and Universitat Internacional de Catalunya (UIC) Barcelona Spain
  • Colin L. Masters
    Florey Institute and The University of Melbourne Melbourne Victoria Australia
  • Barbara Mroczko
    Department of Neurodegeneration Diagnostics Medical University of Bialystok Bialystok Poland
  • Léonor Nogueira
    Laboratoire de Biologie Cellulaire et Cytologie CHU PURPAN Toulouse France
  • Adelina Orellana
    Research Center and Memory Clinic Fundació ACE Institut Català de Neurociències Aplicades and Universitat Internacional de Catalunya (UIC) Barcelona Spain
  • Markus Otto
    Department of Neurology and CSF Laboratory University of Ulm Ulm Germany
  • Jean‐Baptiste Oudart
    CNRS UMR 7369, CHU Reims Université de Reims Champagne‐Ardenne Reims France
  • Claire Paquet
    Université de Paris Cognitive Neurology Center GHU APHP Nord Lariboisière Fernand‐Widal Hospital Paris France
  • Federico Paolini Paoletti
    Lab of Clinical Neurochemistry Section of Neurology Dept. of Medicine and Surgery University of Perugia Perugia Italy
  • Lucilla Parnetti
    Lab of Clinical Neurochemistry Section of Neurology Dept. of Medicine and Surgery University of Perugia Perugia Italy
  • Armand Perret‐Liaudet
    Lyon Neuroscience Research Center BIORAN Team ‐ CNRS UMR 5292 INSERM U1028 Lyon University Hospital Lyon France
  • Katell Peoc'h
    Université de Paris GHU APHP Nord Beaujon Hospital Paris France
  • Koen Poesen
    Laboratory for Molecular Neurobiomarker Research (LaMoN) Department of Neurosciences KU Leuven Leuven Brain Institute Leuven Belgium
  • Albert Puig‐Pijoan
    Servei de Neurologia Hospital del Mar Unitat de deteriorament cognitiu i transtorns del moviment Barcelona Spain
  • Isabelle Quadrio
    Lyon Neuroscience Research Center BIORAN Team ‐ CNRS UMR 5292 INSERM U1028 Lyon University Hospital Lyon France
  • Muriel Quillard‐Muraine
    UNIROUEN Rouen University Hospital Department of Clinical biology Biochemistry laboratory Normandie Univ Rouen France
  • Benoit Rucheton
    DMU BioGeM AP‐HP Sorbonne University Paris France
  • Susanna Schraen
    Inserm CHU Lille U1172‐LilNCog LICEND LabEx DISTALZ Université de Lille Lille France
  • Jonathan M. Schott
    Dementia Research Centre UCL Queen Square Institute of Neurology London UK
  • Leslie M. Shaw
    Department of Pathology and Laboratory Medicine Hospital University of Pennsylvania Pennsylvania USA
  • Marc Suárez‐Calvet
    Barcelonaβeta Brain Research Center (BBRC) Pasqual Maragall Foundation Barcelona Spain
  • Magda Tsolaki
    1st Department of Neurology School of Medicine Faculty of Health of Sciences Aristotle University of Thessaloniki Thessaloniki Greece
  • Hayrettin Tumani
    Department of Neurology and CSF Laboratory University of Ulm Ulm Germany
  • Chinedu T Udeh‐Momoh
    Imperial College London London UK
  • Lucie Vaudran
    CHU Lille Univ. Lille Lille France
  • Marcel M Verbeek
    Donders Institute for Brain, Cognition and Behaviour Radboud Alzheimer Centre Departments of Neurology and Laboratory Medicine Radboud University Medical Center Nijmegen The Netherlands
  • Federico Verde
    Department of Neurology ‐ Stroke Unit and Laboratory of Neuroscience IRCCS Istituto Auxologico Italiano Milan Italy
  • Lisa Vermunt
    Neurochemistry Lab Department of Clinical Chemistry Amsterdam Neuroscience Amsterdam UMC Vrije Universiteit Amsterdam Amsterdam Netherlands
  • Jonathan Vogelgsang
    Department of Psychiatry and Psychotherapy University Medical Center Goettingen (UMG Goettingen Germany
  • Jens Wiltfang
    Department of Psychiatry and Psychotherapy University Medical Center Goettingen (UMG Goettingen Germany
  • Henrik Zetterberg
    Institute of Neuroscience and Physiology The Sahlgrenska Academy at the University of Gothenburg Gothenburg Sweden
  • Sylvain Lehmann
    LBPC‐PPC Univ Montpellier CHU Montpellier INSERM Montpellier France

抄録

<jats:title>Abstract</jats:title><jats:sec><jats:title>Introduction</jats:title><jats:p>The current practice of quantifying cerebrospinal fluid (CSF) biomarkers as an aid in the diagnosis of Alzheimer's disease (AD) varies from center to center. For a same biochemical profile, interpretation and reporting of results may differ, which can lead to misunderstandings and raises questions about the commutability of tests.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>We obtained a description of (pre‐)analytical protocols and sample reports from 40 centers worldwide. A consensus approach allowed us to propose harmonized comments corresponding to the different CSF biomarker profiles observed in patients.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>The (pre‐)analytical procedures were similar between centers. There was considerable heterogeneity in cutoff definitions and report comments. We therefore identified and selected by consensus the most accurate and informative comments regarding the interpretation of CSF biomarkers in the context of AD diagnosis.</jats:p></jats:sec><jats:sec><jats:title>Discussion</jats:title><jats:p>This is the first time that harmonized reports are proposed across worldwide specialized laboratories involved in the biochemical diagnosis of AD.</jats:p></jats:sec>

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