Exploratory Study of the Effectiveness of Granulocyte and Monocyte Adsorptive Apheresis Before Initiation of Steroids in Patients With Active Ulcerative Colitis (EXPECT Study): A Multicenter Prospective Clinical Trial
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- Kazuki Kakimoto
- 2nd Department of Internal Medicine, Osaka Medical College , Takatsuki, Osaka, Japan
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- Minoru Matsuura
- Department of Gastroenterology and Hepatology, Kyorin University School of Medicine , Mitaka, Tokyo, Japan
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- Takumi Fukuchi
- Department of Gastroenterology and Hepatology, Iseikai Hospital , Osaka, Osaka, Japan
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- Hitoshi Hongo
- Department of Gastroenterology, Fujita Gastroenterological Hospital , Takatsuki, Osaka, Japan
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- Tsuguhiro Kimura
- Department of Gastroenterology, Fujita Gastroenterological Hospital , Takatsuki, Osaka, Japan
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- Nobuo Aoyama
- Department of Gastroenterology, Gastrointestinal Endoscopy and IBD Center, Aoyama Medical Clinic , Kobe, Hyogo, Japan
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- Yorihide Okuda
- Department of Gastroenterology, Otemae Hospital , Osaka, Osaka, Japan
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- Kazuki Aomatsu
- Department of Gastroenterology, Izumiotsu Municipal Hospital , Izumiotsu, Osaka, Japan
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- Noriko Kamata
- Department of Gastroenterology, Osaka City University Graduate School of Medicine , Osaka, Osaka, Japan
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- Yoko Yokoyama
- Department of Intestinal Inflammation Research, Hyogo College of Medicine , Nishinomiya, Hyogo, Japan
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- Chiemi Mizuno
- Department of Gastroenterology and Hepatology, Saiseikai Suita Hospital , Suita, Osaka, Japan
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- Takuya Inoue
- 2nd Department of Internal Medicine, Osaka Medical College , Takatsuki, Osaka, Japan
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- Takako Miyazaki
- 2nd Department of Internal Medicine, Osaka Medical College , Takatsuki, Osaka, Japan
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- Shiro Nakamura
- 2nd Department of Internal Medicine, Osaka Medical College , Takatsuki, Osaka, Japan
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- Kazuhide Higuchi
- 2nd Department of Internal Medicine, Osaka Medical College , Takatsuki, Osaka, Japan
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- Hiroshi Nakase
- Department of Gastroenterology and Hepatology, Sapporo Medical University School of Medicine , Sapporo, Hokkaido, Japan
説明
<jats:title>Abstract</jats:title> <jats:sec> <jats:title>Background</jats:title> <jats:p>Granulocyte and monocyte adsorptive apheresis (GMA) has been used for therapy of steroid-dependent/refractory ulcerative colitis (UC). The aim of this study was to investigate the effectiveness of GMA in UC patients not receiving steroids.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods</jats:title> <jats:p>We conducted a single-arm, open-label, and multicenter prospective clinical trial. UC patients who had insufficient responses to 5-aminosalicylic acid received GMA twice a week for 5 weeks.</jats:p> </jats:sec> <jats:sec> <jats:title>Results</jats:title> <jats:p>The response rate of all patients was 58.2% (39/67). Of the 39 patients who achieved a response, 74.4% achieved endoscopically confirmed mucosal healing.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions</jats:title> <jats:p>GMA shows effectiveness in inducing remission in UC patients not receiving steroid.</jats:p> </jats:sec>
収録刊行物
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- Crohn's & Colitis 360
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Crohn's & Colitis 360 2 (4), 2020-09-23
Oxford University Press (OUP)
