Genomic analysis of inherited hearing loss in the Palestinian population
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- Amal Abu Rayyan
- Department of Biology, Bethlehem University, Bethlehem 72372, Palestine;
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- Lara Kamal
- Department of Biology, Bethlehem University, Bethlehem 72372, Palestine;
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- Silvia Casadei
- Department of Medicine, School of Medicine, University of Washington, Seattle, WA 98195-7720;
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- Zippora Brownstein
- Department of Human Molecular Genetics and Biochemistry, Faculty of Medicine, Tel Aviv University, Tel Aviv 6997901, Israel;
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- Fouad Zahdeh
- Department of Biology, Bethlehem University, Bethlehem 72372, Palestine;
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- Hashem Shahin
- Department of Biology, Bethlehem University, Bethlehem 72372, Palestine;
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- Christina Canavati
- Department of Biology, Bethlehem University, Bethlehem 72372, Palestine;
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- Dima Dweik
- Department of Biology, Bethlehem University, Bethlehem 72372, Palestine;
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- Tamara Jaraysa
- Department of Biology, Bethlehem University, Bethlehem 72372, Palestine;
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- Grace Rabie
- Department of Biology, Bethlehem University, Bethlehem 72372, Palestine;
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- Ryan J. Carlson
- Department of Medicine, School of Medicine, University of Washington, Seattle, WA 98195-7720;
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- Suleyman Gulsuner
- Department of Medicine, School of Medicine, University of Washington, Seattle, WA 98195-7720;
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- Ming K. Lee
- Department of Medicine, School of Medicine, University of Washington, Seattle, WA 98195-7720;
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- Karen B. Avraham
- Department of Human Molecular Genetics and Biochemistry, Faculty of Medicine, Tel Aviv University, Tel Aviv 6997901, Israel;
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- Tom Walsh
- Department of Medicine, School of Medicine, University of Washington, Seattle, WA 98195-7720;
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- Mary-Claire King
- Department of Medicine, School of Medicine, University of Washington, Seattle, WA 98195-7720;
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- Moien N. Kanaan
- Department of Biology, Bethlehem University, Bethlehem 72372, Palestine;
説明
<jats:title>Significance</jats:title> <jats:p>The genetic characterization of a common phenotype for an entire population reveals both the genetic epidemiology of that phenotype and the power of family-based, population-wide genomic analysis. We characterized the genetics of hearing loss throughout the Palestinian population of the West Bank and Gaza. In families with no prior history of hearing loss, we estimate that 56% of hearing loss is genetic and 44% is not genetic. For most families with inherited hearing loss, causal genes and mutations were identified. Most inherited hearing loss in the population was attributable to consanguinity. Given the ongoing decline in consanguineous marriage, inherited hearing loss will likely be much rarer in the next generation.</jats:p>
収録刊行物
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- Proceedings of the National Academy of Sciences
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Proceedings of the National Academy of Sciences 117 (33), 20070-20076, 2020-08-03
Proceedings of the National Academy of Sciences