Interferon-Induced Transmembrane Protein 1 Restricts Replication of Viruses That Enter Cells via the Plasma Membrane
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- S. E. Smith
- Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom
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- D. C. Busse
- Mucosal Infection and Immunity Group, Section of Virology, Imperial College London, St. Mary’s Campus, London, United Kingdom
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- S. Binter
- Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom
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- S. Weston
- MRC Laboratory for Molecular Cell Biology, University College London, London, United Kingdom
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- C. Diaz Soria
- Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom
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- B. M. Laksono
- Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands
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- S. Clare
- Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom
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- S. Van Nieuwkoop
- Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands
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- B. G. Van den Hoogen
- Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands
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- M. Clement
- Division of Infection and Immunity/Systems Immunity University Research Institute, Cardiff University, Cardiff, United Kingdom
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- M. Marsden
- Division of Infection and Immunity/Systems Immunity University Research Institute, Cardiff University, Cardiff, United Kingdom
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- I. R. Humphreys
- Division of Infection and Immunity/Systems Immunity University Research Institute, Cardiff University, Cardiff, United Kingdom
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- M. Marsh
- MRC Laboratory for Molecular Cell Biology, University College London, London, United Kingdom
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- R. L. de Swart
- Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands
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- R. S. Wash
- Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom
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- J. S. Tregoning
- Mucosal Infection and Immunity Group, Section of Virology, Imperial College London, St. Mary’s Campus, London, United Kingdom
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- P. Kellam
- Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom
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- Terence S. Dermody
- editor
書誌事項
- 公開日
- 2019-03-15
- 権利情報
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- https://creativecommons.org/licenses/by/4.0/
- https://journals.asm.org/non-commercial-tdm-license
- DOI
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- 10.1128/jvi.02003-18
- 公開者
- American Society for Microbiology
この論文をさがす
説明
<jats:p> Host susceptibility to viral infection is multifactorial, but early control of viruses not previously encountered is predominantly mediated by the interferon-stimulated gene (ISG) family. There are upwards of 300 of these genes, the majority of which do not have a clearly defined function or mechanism of action. The cellular location of these proteins may have an important effect on their function. One ISG located at the plasma membrane is interferon-inducible transmembrane protein 1 (IFITM1). Here we demonstrate that IFITM1 can inhibit infection with a range of viruses that enter via the plasma membrane. Mutant IFITM1 proteins that were unable to localize to the plasma membrane did not restrict viral infection. We also observed for the first time that IFITM1 plays a role <jats:italic>in vivo</jats:italic> , and <jats:italic> Ifitm1 <jats:sup>−/−</jats:sup> </jats:italic> mice were more susceptible to viral lung infection. These data contribute to our understanding of how ISGs prevent viral infections. </jats:p>
収録刊行物
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- Journal of Virology
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Journal of Virology 93 (6), e02003-, 2019-03-15
American Society for Microbiology