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- Roni Nowarski
- Authors' Affiliations: 1Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut; 2I. Medizinsche Klinik und Poliklink, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; and 3Howard Hughes Medical Institute, Chevy Chase, Maryland
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- Nicola Gagliani
- Authors' Affiliations: 1Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut; 2I. Medizinsche Klinik und Poliklink, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; and 3Howard Hughes Medical Institute, Chevy Chase, Maryland
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- Samuel Huber
- Authors' Affiliations: 1Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut; 2I. Medizinsche Klinik und Poliklink, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; and 3Howard Hughes Medical Institute, Chevy Chase, Maryland
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- Richard A. Flavell
- Authors' Affiliations: 1Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut; 2I. Medizinsche Klinik und Poliklink, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; and 3Howard Hughes Medical Institute, Chevy Chase, Maryland
説明
<jats:title>Abstract</jats:title> <jats:p>The innate immune system has evolved in multicellular organisms to detect and respond to situations that compromise tissue homeostasis. It comprises a set of tissue-resident and circulating leukocytes primarily designed to sense pathogens and tissue damage through hardwired receptors and eliminate noxious sources by mediating inflammatory processes. While indispensable to immunity, the inflammatory mediators produced in situ by activated innate cells during injury or infection are also associated with increased cancer risk and tumorigenesis. Here, we outline basic principles of innate immune cell functions in inflammation and discuss how these functions converge upon cancer development. Cancer Immunol Res; 1(2); 77–84. ©2013 AACR.</jats:p>
収録刊行物
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- Cancer Immunology Research
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Cancer Immunology Research 1 (2), 77-84, 2013-08-01
American Association for Cancer Research (AACR)
