Electrocorticography reveals thalamic control of cortical dynamics following traumatic brain injury
書誌事項
- 公開日
- 2021-10-21
- 権利情報
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- https://creativecommons.org/licenses/by/4.0
- https://creativecommons.org/licenses/by/4.0
- DOI
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- 10.1038/s42003-021-02738-2
- 公開者
- Springer Science and Business Media LLC
説明
<jats:title>Abstract</jats:title><jats:p>The return of consciousness after traumatic brain injury (TBI) is associated with restoring complex cortical dynamics; however, it is unclear what interactions govern these complex dynamics. Here, we set out to uncover the mechanism underlying the return of consciousness by measuring local field potentials (LFP) using invasive electrophysiological recordings in patients recovering from TBI. We found that injury to the thalamus, and its efferent projections, on MRI were associated with repetitive and low complexity LFP signals from a highly structured phase space, resembling a low-dimensional ring attractor. But <jats:italic>why do thalamic injuries in TBI patients result in a cortical attractor</jats:italic>? We built a simplified thalamocortical model, which connotes that thalamic input facilitates the formation of cortical ensembles required for the return of cognitive function and the <jats:italic>content</jats:italic> of consciousness. These observations collectively support the view that thalamic input to the cortex enables rich cortical dynamics associated with consciousness.</jats:p>
収録刊行物
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- Communications Biology
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Communications Biology 4 (1), 1210-, 2021-10-21
Springer Science and Business Media LLC