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- Yun-Feng Zheng
- School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China
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- Juan-Hua Wei
- School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China
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- Shi-Qi Fang
- School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China
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- Yu-Ping Tang
- School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China
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- Hai-Bo Cheng
- Translational Medicine Research Center of Nanjing University of Chinese Medicine, Nanjing 210023, China
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- Tian-Lin Wang
- School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China
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- Cun-Yu Li
- School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China
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- Guo-Ping Peng
- School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China
書誌事項
- 公開日
- 2015-04-09
- 権利情報
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- https://creativecommons.org/licenses/by/4.0/
- DOI
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- 10.3390/molecules20046273
- 公開者
- MDPI AG
説明
<jats:p>Two novel oleanane-type triterpene saponins, licorice-saponin P2 (1) and licorice-saponin Q2 (3), together with nine known compounds 2, 4–11, have been isolated from the water extract of the roots of Glycyrrhiza inflata. The structures of these compounds were elucidated on the basis of spectroscopic analysis, including 2D-NMR experiments (1H–1H COSY, HSQC, HMBC and ROESY). In in vitro assays, compounds 2–4, 6 and 11 showed significant hepatoprotective activities by lowering the ALT and AST levels in primary rat hepatocytes injured by D-galactosamine (D-GalN). In addition, compounds 2–4, 6, 7 and 11 were found to inhibit the activity of PLA2 with IC50 values of 6.9 μM, 3.6 μM, 16.9 μM, 27.1 μM, 32.2 μM and 9.3 μM, respectively, which might be involved in the regulation of the hepatoprotective activities observed.</jats:p>
収録刊行物
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- Molecules
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Molecules 20 (4), 6273-6283, 2015-04-09
MDPI AG