Evaluating pH in the Extracellular Tumor Microenvironment Using CEST MRI and Other Imaging Methods
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- Liu Qi Chen
- Department of Chemistry and Biochemistry, University of Arizona, Tucson, AZ 85721, USA
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- Mark D. Pagel
- Department of Chemistry and Biochemistry, University of Arizona, Tucson, AZ 85721, USA
書誌事項
- 公開日
- 2015-07-01
- 権利情報
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- http://creativecommons.org/licenses/by/3.0/
- DOI
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- 10.1155/2015/206405
- 公開者
- Hindawi Limited
この論文をさがす
説明
<jats:p>Tumor acidosis is a consequence of altered metabolism, which can lead to chemoresistance and can be a target of alkalinizing therapies. Noninvasive measurements of the extracellular pH (pHe) of the tumor microenvironment can improve diagnoses and treatment decisions. A variety of noninvasive imaging methods have been developed for measuring tumor pHe. This review provides a detailed description of the advantages and limitations of each method, providing many examples from previous research reports. A substantial emphasis is placed on methods that use MR spectroscopy and MR imaging, including recently developed methods that use chemical exchange saturation transfer MRI that combines some advantages of MR spectroscopy and imaging. Together, this review provides a comprehensive overview of methods for measuring tumor pHe, which may facilitate additional creative approaches in this research field.</jats:p>
収録刊行物
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- Advances in Radiology
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Advances in Radiology 2015 1-25, 2015-07-01
Hindawi Limited