International collaborative study to assess cardiovascular risk and evaluate long‐term health in cats with preclinical hypertrophic cardiomyopathy and apparently healthy cats: The REVEAL Study
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- Philip R. Fox
- Department of Cardiology and Caspary Research Institute The Animal Medical Center New York New York U.S.A.
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- Bruce W. Keene
- Department of Clinical Sciences, North Carolina State University Raleigh North Carolina U.S.A.
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- Kenneth Lamb
- Lamb Consulting Minneapolis Minnesota U.S.A.
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- Karsten A. Schober
- Department of Veterinary Clinical Sciences The Ohio State University Columbus Ohio U.S.A.
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- Valerie Chetboul
- Alfort Cardiology Unit Ecole Nationale Vétérinaire d'Alfort Maisons‐Alfort Cedex France
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- Virginia Luis Fuentes
- Department of Veterinary Clinical Sciences and Services The Royal Veterinary College Hatfield, Hertfordshire United Kingdom
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- Gerhard Wess
- Clinic of Small Animal Medicine Ludwig‐Maximilians University Munich Germany
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- Jessie Rose Payne
- Department of Veterinary Clinical Sciences and Services The Royal Veterinary College Hatfield, Hertfordshire United Kingdom
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- Daniel F. Hogan
- Department of Veterinary Clinical Sciences Purdue University West Lafayette Indiana U.S.A.
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- Alison Motsinger‐Reif
- Department of Statistics, North Carolina State University Raleigh North Carolina U.S.A.
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- Jens Häggström
- Department of Clinical Sciences, Swedish University of Agricultural Sciences Uppsala Sweden
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- Emilie Trehiou‐Sechi
- Alfort Cardiology Unit Ecole Nationale Vétérinaire d'Alfort Maisons‐Alfort Cedex France
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- Deborah M. Fine‐Ferreira
- Department of Veterinary Medicine and Surgery University of Missouri Columbia Missouri U.S.A.
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- Reid K. Nakamura
- Advanced Veterinary Care Center Lawndale California U.S.A.
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- Pamela M. Lee
- Department of Cardiology and Caspary Research Institute The Animal Medical Center New York New York U.S.A.
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- Manreet K. Singh
- William R. Pritchard Veterinary Medical Teaching Hospital, University of California‐Davis Davis California U.S.A.
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- Wendy A. Ware
- Department of Veterinary Clinical Sciences Iowa State University Ames Iowa U.S.A.
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- Jonathan A. Abbott
- Department of Small Animal Clinical Sciences Virginia‐Maryland Regional College of Veterinary Medicine Blacksburg Virginia, U.S.A.
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- Geoffrey Culshaw
- Royal (Dick) SVS Hospital for Small Animals, The University of Edinburgh Roslin Midlothian United Kingdom
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- Sabine Riesen
- Department for Companion Animals and Horses University of Veterinary Medicine Vienna Austria
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- Michele Borgarelli
- Department of Clinical Sciences Kansas State University Manhattan Kansas U.S.A.
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- Michael B. Lesser
- Advanced Veterinary Care Center Lawndale California U.S.A.
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- Nicole Van Israël
- Animal CardioPulmonary Consultancy Masta Stavelot, Belgium
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- Etienne Côté
- Department of Companion Animals Atlantic Veterinary College, University of Prince Edward Island Charlottetown Prince Edward Island Canada
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- John E. Rush
- Department of Clinical Sciences Tufts University, Cummings School of Veterinary Medicine North Grafton Massachusetts U.S.A.
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- Barret Bulmer
- Tufts Veterinary Emergency Treatment & Specialties Walpole Massachusetts U.S.A.
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- Roberto A. Santilli
- Department of Cardiology Clinica Veterinaria Malpensa Varese Italy
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- Andrea C. Vollmar
- Fachtieraerztin fur Kleintiere Wissen and Bonn Germany
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- Maribeth J. Bossbaly
- Veterinary Specialty and Emergency Center Levittown Pennsylvania U.S.A.
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- Nadine Quick
- Clinic of Small Animal Medicine Ludwig‐Maximilians University Munich Germany
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- Claudio Bussadori
- Department of Cardiology, Clinica Veterinaria Gran Sasso Milan Italy
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- Janice M. Bright
- Department of Clinical Sciences Colorado State University Fort Collins Colorado U.S.A.
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- Amara H. Estrada
- Department of Small Animal Clinical Sciences University of Florida Gainesville Florida
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- Dan G. Ohad
- Department of Clinical Sciences, The Koret School of Veterinary Medicine Rehovot Israel
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- Maria Josefa Fernández‐Del Palacio
- Departamento de Medicina y Cirugía Animal Universidad de Murcia Murcia Spain
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- Jenifer Lunney Brayley
- Veterinary Medical Specialists of Houston Houston Texas U.S.A.
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- Denise S. Schwartz
- Department of Internal Medicine University of São Paulo São Paulo Brazil
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- Christina M. Bové
- Department of Clinical Studies, University of Guelph Guelph Ontario Canada
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- Sonya G. Gordon
- Department of Small Animal Clinical Sciences Texas A&M University College Station Texas U.S.A.
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- Seung Woo Jung
- William R. Pritchard Veterinary Medical Teaching Hospital, University of California‐Davis Davis California, U.S.A.
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- Paola Brambilla
- Department of Veterinary Medicine University of Milan Milan Italy
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- N. Sydney Moïse
- Department of Clinical Sciences Cornell University Ithaca New York U.S.A.
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- Christopher D. Stauthammer
- Department of Veterinary Clinical Sciences University of Minnesota St. Paul Minnesota U.S.A.
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- Rebecca L. Stepien
- Department of Medical Sciences University of Wisconsin School of Veterinary Medicine Madison Wisconsin U.S.A.
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- Cecilia Quintavalla
- Department of Veterinary Sciences University of Parma Parma Italy
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- Christophe Amberger
- Cabinet Vétérinaire et Centre d'Imagerie Geneva Switzerland
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- Ferenc Manczur
- Department of Internal Medicine University of Veterinary Medicine Budapest Hungary
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- Yong‐Wei Hung
- Cardiospecial Veterinary Hospital Taipei Taiwan
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- Remo Lobetti
- Bryanston Veterinary Hospital Bryanston South Africa
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- Marie De Swarte
- University College Dublin Veterinary Hospital University College Dublin Dublin Ireland
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- Alice Tamborini
- University College Dublin Veterinary Hospital University College Dublin Dublin Ireland
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- Carmel T. Mooney
- University College Dublin Veterinary Hospital University College Dublin Dublin Ireland
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- Mark A. Oyama
- Department of Clinical Studies University of Pennsylvania Philadelphia Pennsylvania U.S.A.
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- Andrey Komolov
- Veterinary Clinic Beliy Klyk Moscow Russia
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- Yoko Fujii
- Azabu University Sagamihara Kanagawa Japan
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- Romain Pariaut
- Department of Veterinary Clinical Sciences Louisiana State University Baton Rouge, Louisiana U.S.A.
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- Masami Uechi
- Jasmine Animal Cardiovascular Center Yokohama Kanagawa Japan
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- Victoria Yukie Tachika Ohara
- Department of Medicine Surgery and Zootechnics for Small Species, Universidad Nacional Autónoma de México Mexico City Mexico
説明
<jats:sec><jats:title>Background</jats:title><jats:p>Hypertrophic cardiomyopathy is the most prevalent heart disorder in cats and principal cause of cardiovascular morbidity and mortality. Yet, the impact of preclinical disease is unresolved.</jats:p></jats:sec><jats:sec><jats:title>Hypothesis/Objectives</jats:title><jats:p>Observational study to characterize cardiovascular morbidity and survival in cats with preclinical nonobstructive (HCM) and obstructive (HOCM) hypertrophic cardiomyopathy and in apparently healthy cats (AH).</jats:p></jats:sec><jats:sec><jats:title>Animals</jats:title><jats:p>One thousand seven hundred and thirty client‐owned cats (430 preclinical HCM; 578 preclinical HOCM; 722 AH).</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Retrospective multicenter, longitudinal, cohort study. Cats from 21 countries were followed through medical record review and owner or referring veterinarian interviews. Data were analyzed to compare long‐term outcomes, incidence, and risk for congestive heart failure (CHF), arterial thromboembolism (ATE), and cardiovascular death.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>During the study period, CHF, ATE, or both occurred in 30.5% and cardiovascular death in 27.9% of 1008 HCM/HOCM cats. Risk assessed at 1, 5, and 10 years after study entry was 7.0%/3.5%, 19.9%/9.7%, and 23.9%/11.3% for CHF/ATE, and 6.7%, 22.8%, and 28.3% for cardiovascular death, respectively. There were no statistically significant differences between HOCM compared with HCM for cardiovascular morbidity or mortality, time from diagnosis to development of morbidity, or cardiovascular survival. Cats that developed cardiovascular morbidity had short survival (mean ± standard deviation, 1.3 ± 1.7 years). Overall, prolonged longevity was recorded in a minority of preclinical HCM/HOCM cats with 10% reaching 9‐15 years.</jats:p></jats:sec><jats:sec><jats:title>Conclusions and Clinical Importance</jats:title><jats:p>Preclinical HCM/HOCM is a global health problem of cats that carries substantial risk for CHF, ATE, and cardiovascular death. This finding underscores the need to identify therapies and monitoring strategies that decrease morbidity and mortality.</jats:p></jats:sec>
収録刊行物
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- Journal of Veterinary Internal Medicine
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Journal of Veterinary Internal Medicine 32 (3), 930-943, 2018-04-16
Wiley
- Tweet
キーワード
- Male
- arterial thromboembolism; asymptomatic; congestive heart failure; epidemiology; incidence; out-come; survival
- 610
- Cat Diseases
- survival
- Risk Factors
- asymptomatic
- Animals
- arterial thromboembolism
- arterial thromboembolism; asymptomatic; congestive heart failure; epidemiology; incidence; outcome; survival
- Retrospective Studies
- Incidence
- Age Factors
- Cardiomyopathy, Hypertrophic
- Survival Analysis
- congestive heart failure
- Cardiovascular Diseases
- Echocardiography
- Case-Control Studies
- incidence
- outcome
- Cats
- epidemiology
- Female
- SMALL ANIMAL
詳細情報 詳細情報について
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- CRID
- 1360580240050888320
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- ISSN
- 19391676
- 08916640
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- PubMed
- 30417429
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- データソース種別
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- Crossref
- OpenAIRE
