The effects of hypoglycemia and weight loss of total lignans from <i>Fructus Arctii</i> in KKAy mice and its mechanisms of the activity

DOI Web Site Web Site 被引用文献1件
  • Yingying Gao
    Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine Ministry of Education, Shanghai University of Traditional Chinese Medicine Shanghai 201203 China
  • Chenchen Gu
    Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine Ministry of Education, Shanghai University of Traditional Chinese Medicine Shanghai 201203 China
  • Kai Wang
    Center for Drug Safety Evaluation Shanghai University of Traditional Chinese Medicine Shanghai 201203 China
  • Haiying Wang
    School of Pharmacy Shanghai University of Traditional Chinese Medicine Shanghai 201203 China
  • Kefeng Ruan
    Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine Ministry of Education, Shanghai University of Traditional Chinese Medicine Shanghai 201203 China
  • Zhaohui Xu
    Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine Ministry of Education, Shanghai University of Traditional Chinese Medicine Shanghai 201203 China
  • Yi Feng
    Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine Ministry of Education, Shanghai University of Traditional Chinese Medicine Shanghai 201203 China

書誌事項

公開日
2017-12-13
権利情報
  • http://onlinelibrary.wiley.com/termsAndConditions#vor
DOI
  • 10.1002/ptr.6003
公開者
Wiley

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説明

<jats:p><jats:italic>Fructus Arctii</jats:italic> (great burdock achene) is the dried ripe fruit of <jats:styled-content style="fixed-case"><jats:italic>Arctium lappa</jats:italic></jats:styled-content> L. (family Asteraceae) and is included in the Chinese pharmacopoeia. It has been reported that the clinical use of <jats:italic>Fructus Arctii</jats:italic> resulted in a satisfactory hypoglycemic effect in diabetic patients. This study aimed to investigate antidiabetic activity and mechanism of total lignans from <jats:italic>Fructus Arctii</jats:italic> (TLFA) in KKAy mice, a spontaneous Type 2 diabetic rodent model that exhibits marked obesity. In this study, KKAy mice were gavaged once daily with solvents (0.5% sodium carboxymethyl cellulose), TLFA (250 and 125 mg/kg), or metformin (200 mg/kg) for 11 weeks, and C57BL/6J mice treated with saline solution (0.9%, <jats:italic>w</jats:italic>/<jats:italic>v</jats:italic>) were used as normal control. The results indicate that TLFA has dual effects of hypoglycemia and weight loss, and administration of TLFA in KKAy mice could decrease fasting blood glucose, glycated hemoglobin, and body weight; improve oral glucose tolerance; increase high density lipoprotein cholesterol; and decrease triglycerides and free fatty acid in mice serum. Its efficacy may associate with multiple mechanisms of action such as stimulation of insulin secretion, activation of phosphatidylinositol 3‐kinase/protein kinase B, and adenosine‐monophosphate‐activated protein kinase signaling pathway, decreasing leptin.</jats:p>

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