Microfluidic‐Based Approaches in Targeted Cell/Particle Separation Based on Physical Properties: Fundamentals and Applications
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- Rohollah Nasiri
- Center for Minimally Invasive Therapeutics (C‐MIT) University of California, Los Angeles Los Angeles CA 90095 USA
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- Amir Shamloo
- Department of Mechanical Engineering Sharif University of Technology Tehran 11365‐11155 Iran
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- Samad Ahadian
- Center for Minimally Invasive Therapeutics (C‐MIT) University of California, Los Angeles Los Angeles CA 90095 USA
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- Leyla Amirifar
- Department of Mechanical Engineering Sharif University of Technology Tehran 11365‐11155 Iran
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- Javad Akbari
- Department of Mechanical Engineering Sharif University of Technology Tehran 11365‐11155 Iran
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- Marcus J. Goudie
- Center for Minimally Invasive Therapeutics (C‐MIT) University of California, Los Angeles Los Angeles CA 90095 USA
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- KangJu Lee
- Center for Minimally Invasive Therapeutics (C‐MIT) University of California, Los Angeles Los Angeles CA 90095 USA
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- Nureddin Ashammakhi
- Center for Minimally Invasive Therapeutics (C‐MIT) University of California, Los Angeles Los Angeles CA 90095 USA
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- Mehmet R. Dokmeci
- Center for Minimally Invasive Therapeutics (C‐MIT) University of California, Los Angeles Los Angeles CA 90095 USA
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- Dino Di Carlo
- Department of Bioengineering University of California, Los Angeles Los Angeles CA 90095 USA
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- Ali Khademhosseini
- Center for Minimally Invasive Therapeutics (C‐MIT) University of California, Los Angeles Los Angeles CA 90095 USA
抄録
<jats:title>Abstract</jats:title><jats:p>Cell separation is a key step in many biomedical research areas including biotechnology, cancer research, regenerative medicine, and drug discovery. While conventional cell sorting approaches have led to high‐efficiency sorting by exploiting the cell's specific properties, microfluidics has shown great promise in cell separation by exploiting different physical principles and using different properties of the cells. In particular, label‐free cell separation techniques are highly recommended to minimize cell damage and avoid costly and labor‐intensive steps of labeling molecular signatures of cells. In general, microfluidic‐based cell sorting approaches can separate cells using “intrinsic” (e.g., fluid dynamic forces) versus “extrinsic” external forces (e.g., magnetic, electric field, etc.) and by using different properties of cells including size, density, deformability, shape, as well as electrical, magnetic, and compressibility/acoustic properties to select target cells from a heterogeneous cell population. In this work, principles and applications of the most commonly used label‐free microfluidic‐based cell separation methods are described. In particular, applications of microfluidic methods for the separation of circulating tumor cells, blood cells, immune cells, stem cells, and other biological cells are summarized. Computational approaches complementing such microfluidic methods are also explained. Finally, challenges and perspectives to further develop microfluidic‐based cell separation methods are discussed.</jats:p>
収録刊行物
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- Small
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Small 16 (29), 1-, 2020-06-11
Wiley