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- Jong-Eun Park
- Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
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- Laura Jardine
- Biosciences Institute, Newcastle University, Faculty of Medical Sciences, Newcastle upon Tyne NE2 4HH, UK.
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- Berthold Gottgens
- Department of Haematology, University of Cambridge, Cambridge CB2 2XY, UK.
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- Sarah A. Teichmann
- Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
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- Muzlifah Haniffa
- Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
書誌事項
- 公開日
- 2020-05-08
- DOI
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- 10.1126/science.aaz9330
- 公開者
- American Association for the Advancement of Science (AAAS)
この論文をさがす
説明
<jats:p>The blood and immune systems develop in parallel during early prenatal life. Waves of hematopoiesis separated in anatomical space and time give rise to circulating and tissue-resident immune cells. Previous observations have relied on animal models, which differ from humans in both their developmental timeline and exposure to microorganisms. Decoding the composition of the human immune system is now tractable using single-cell multi-omics approaches. Large-scale single-cell genomics, imaging technologies, and the Human Cell Atlas initiative have together enabled a systems-level mapping of the developing human immune system and its emergent properties. Although the precise roles of specific immune cells during development require further investigation, the system as a whole displays malleable and responsive properties according to developmental need and environmental challenge.</jats:p>
収録刊行物
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- Science
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Science 368 (6491), 600-603, 2020-05-08
American Association for the Advancement of Science (AAAS)