Coordinating bioorthogonal reactions with two tumor-microenvironment-responsive nanovehicles for spatiotemporally controlled prodrug activation

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Abstract

<p>Spatiotemporally controlled activation: Dox-TCO loaded low pH-sensitive nanovehicles and Tz-containing MMP-2-sensitive nanocarriers simultaneously dissociated in tumor microenvironment, with Dox locally liberated through IEDDA biorthogonal reaction.</p>

Journal

  • Chemical Science

    Chemical Science 11 (8), 2155-2160, 2020

    Royal Society of Chemistry (RSC)

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