Genetic Polymorphisms and Susceptibility to Sudden Sensorineural Hearing Loss: A Systematic Review
書誌事項
- 公開日
- 2019
- 権利情報
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- https://www.karger.com/Services/SiteLicenses
- https://www.karger.com/Services/SiteLicenses
- DOI
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- 10.1159/000497032
- 公開者
- S. Karger AG
この論文をさがす
説明
<jats:p>Background: Recently, genetic factors have been considered as an important risk factor for sudden sensorineural hearing loss (SSNHL). Many studies analyzed the association between SSNHL and polymorphisms. However, most of them gave inconclusive results. Key Message: We performed a systematic review to find out the association between polymorphisms and susceptibility to SSNHL. Finally, 47 studies involving 5,230 SSNHL patients and 68 genes were included for analysis and discussion of results. Polymorphisms in 26 genes have been suggested to be correlated with the susceptibility to SSNHL. Summary: Although a great number of studies support that polymorphisms in genes are associated with susceptibility to SSNHL, we need large multicenter studies, which evaluate multiple single nucleotide polymorphisms in SSNHL patients, to find real genetic risk factors for susceptibility to SSNHL. This is very helpful in designing more effective prevention and treatment strategies for patients with SSNHL.</jats:p>
収録刊行物
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- Audiology and Neurotology
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Audiology and Neurotology 24 (1), 8-19, 2019
S. Karger AG
