Celastrol binds to its target protein <i>via</i> specific noncovalent interactions and reversible covalent bonds
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- Duo Zhang
- School of Pharmaceutical Sciences
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- Ziwen Chen
- School of Pharmaceutical Sciences
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- Chaochao Hu
- School of Pharmaceutical Sciences
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- Siwei Yan
- School of Pharmaceutical Sciences
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- Zhuoer Li
- School of Pharmaceutical Sciences
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- Baohuan Lian
- School of Pharmaceutical Sciences
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- Yang Xu
- School of Pharmaceutical Sciences
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- Rong Ding
- School of Pharmaceutical Sciences
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- Zhiping Zeng
- School of Pharmaceutical Sciences
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- Xiao-kun Zhang
- School of Pharmaceutical Sciences
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- Ying Su
- School of Pharmaceutical Sciences
説明
<p>Celastrol binding to its target protein Nur77 requires specific noncovalent interactions that position celastrol close to a specific cysteine and furthermore confer its binding specificity.</p>
収録刊行物
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- Chemical Communications
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Chemical Communications 54 (91), 12871-12874, 2018
Royal Society of Chemistry (RSC)