Estimating the age of mutations using variation at linked markers

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<jats:title>Abstract</jats:title> <jats:p>We present a general method for estimating the dates of mutations using variation at linked microsatellite markers. Risch et al. ( 1995) take a similar approach to estimating the age of the mutation causing idiopathic torsion dystonia among Ashkenazic Jews, but they do not describe how to produce a confidence interval for the date. Here, we not only obtain a confidence interval for the date by assessing the degree of correlation among samples, but also describe how to use a Markov transition matrix approach to take full account of the complexities of the recombination process. Finally, we show how the method has been applied to a specific example: estimation of a date for a mutation that confers resistance to HIV-1 infection (Stephens et al. 1998).</jats:p>

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