Association between Granulomatous Colitis in French Bulldogs and Invasive <i>Escherichia coli</i> and Response to Fluoroquinolone Antimicrobials
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- A.C. Manchester
- College of Veterinary Medicine Cornell University Ithaca NY
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- S. Hill
- the Department of Internal Medicine the Veterinary Specialty Hospital San Diego CA
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- B. Sabatino
- College of Veterinary Medicine University of Ten‐nessee Knoxville TN
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- R. Armentano
- College of Veterinary Medicine University of Florida Gainesville FL
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- M. Carroll
- Department of Internal Medicine Angell Animal Medical Center Boston MA
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- B. Kessler
- College of Veterinary Medicine Cornell University Ithaca NY
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- M. Miller
- College of Veterinary Medicine Cornell University Ithaca NY
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- B. Dogan
- College of Veterinary Medicine Cornell University Ithaca NY
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- S.P. McDonough
- College of Veterinary Medicine Cornell University Ithaca NY
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- K.W. Simpson
- College of Veterinary Medicine Cornell University Ithaca NY
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説明
<jats:sec><jats:title>Background</jats:title><jats:p>French Bulldogs develop a form of granulomatous colitis (<jats:styled-content style="fixed-case">GC</jats:styled-content>) with histopathological resemblance to <jats:styled-content style="fixed-case">GC</jats:styled-content> of Boxer dogs (<jats:styled-content style="fixed-case">GCB</jats:styled-content>). <jats:styled-content style="fixed-case">GCB</jats:styled-content> is associated with mucosally invasive <jats:italic>Escherichia coli</jats:italic> whose eradication correlates with clinical remission.</jats:p></jats:sec><jats:sec><jats:title>Hypothesis/Objectives</jats:title><jats:p>To characterize the clinical and histopathological features, presence or absence of invasive colonic bacteria, and response to fluoroquinolones in French Bulldogs with <jats:styled-content style="fixed-case">GC</jats:styled-content>.</jats:p></jats:sec><jats:sec><jats:title>Animals</jats:title><jats:p>A total of 6 French Bulldogs with a histological diagnosis of <jats:styled-content style="fixed-case">GC</jats:styled-content>.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Retrospective study of medical records. Bacterial colonization was evaluated using 16S r<jats:styled-content style="fixed-case">RNA</jats:styled-content> probes for eubacteria and <jats:italic>E. coli</jats:italic>. Biopsy specimens from 3 dogs were cultured for bacteria. Clinical response to fluoroquinolone antimicrobials was determined.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>All dogs were ≤1 year of age with hematochezia that was refractory to empirical therapy. Clinicopathologic and fecal analysis did not reveal abnormalities. Abdominal ultrasound revealed patchy thickening of the colon in 4/5 dogs and regional lymphadenopathy in 5/5. Colonoscopic abnormalities included irregularly thickened and ulcerated mucosa, hyperemia, and overt bleeding in 4/6 cases. Multifocal accumulations of <jats:styled-content style="fixed-case">PAS</jats:styled-content>‐positive macrophages and intramucosal <jats:italic>E. coli</jats:italic> were present in colonic biopsies of all 6 dogs. Administration of enrofloxacin (5/6) or marbofloxacin (1/6) at 4.4–10 mg/kg (median 10 mg/kg) <jats:styled-content style="fixed-case">PO</jats:styled-content> q24h for 6–10 weeks was associated with clinical improvement within 5–14 days. All dogs remained in remission over a 3–30 month follow‐up period.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>Granulomatous colitis in young French Bulldogs is associated with the presence of invasive <jats:italic>E. coli</jats:italic> and closely parallels <jats:styled-content style="fixed-case">GCB</jats:styled-content>. Treatment with fluoroquinolone antimicrobials can induce lasting clinical remission.</jats:p></jats:sec>
収録刊行物
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- Journal of Veterinary Internal Medicine
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Journal of Veterinary Internal Medicine 27 (1), 56-61, 2012-12-03
Wiley