Activatable 19F MRI probe for detection of α-amylase activity

DOI PDF PDF 参考文献29件
  • Yuki Konishi
    Graduate School of Engineering, Osaka University , 2-1 Yamadaoka, Suita , Osaka 565-0871, Japan
  • Yuya Otera
    Graduate School of Engineering, Osaka University , 2-1 Yamadaoka, Suita , Osaka 565-0871, Japan
  • Masafumi Minoshima
    Graduate School of Engineering, Osaka University , 2-1 Yamadaoka, Suita , Osaka 565-0871, Japan
  • Kazuya Kikuchi
    Graduate School of Engineering, Osaka University , 2-1 Yamadaoka, Suita , Osaka 565-0871, Japan

説明

<jats:title>Abstract</jats:title> <jats:p>α-Amylase is an endo-type glycoside hydrolase and has drawn attention as a biomarker of various diseases. However, current detection methods rely on colorimetric and fluorometric approaches, which limits imaging in deep tissues. In this research, we developed an activatable probe, Tfb-G6-Gd, for detecting α-amylase using 19F MRI. In the presence of α-amylase, the 19F MRI signal of Tfb-G6-Gd increased by attenuation of paramagnetic relaxation enhancement effect. This probe showed a switching ability depending on α-amylase activity with high specificity.</jats:p>

収録刊行物

参考文献 (29)*注記

もっと見る

関連プロジェクト

もっと見る

詳細情報 詳細情報について

問題の指摘

ページトップへ