Lincosamide Antibiotics: Structure, Activity, and Biosynthesis

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  • Takahiro Mori
    Graduate School of Pharmaceutical Sciences The University of Tokyo 7-3-1 Hongo, Bunkyo-ku Tokyo 113-0033 Japan
  • Ikuro Abe
    Graduate School of Pharmaceutical Sciences The University of Tokyo 7-3-1 Hongo, Bunkyo-ku Tokyo 113-0033 Japan

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<jats:title>Abstract</jats:title><jats:p>Lincosamides are naturally occurring antibiotics isolated from <jats:italic>Streptomyces</jats:italic> sp. Currently, lincomycin A and its semisynthetic analogue clindamycin are used as clinical drugs. Due to their unique structures and remarkable biological activities, derivatizations of lincosamides via semi‐synthesis and biosynthetic studies have been reported. This review summarizes the structures and biological activities of lincosamides, and the recent studies of lincosamide biosynthetic enzymes.</jats:p>

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