Dryoptkirbioside, A New Fructofuranoside Glycerol, and Other Constituents from <i>Dryopteris kirbi</i> Hook et Grav Rhizomes

  • Marie Germaine T. Matchide
    Natural Products Chemistry Research Unit Department of Chemistry Faculty of Science University of Dschang P.O. Box 67 Dschang Cameroon
  • Saw Yu Yu Hnin
    Institute of Natural Medicine University of Toyama 2630-Sugitani Toyama 930-0194 Japan
  • Yves M. Mba Nguekeu
    Natural Products Chemistry Research Unit Department of Chemistry Faculty of Science University of Dschang P.O. Box 67 Dschang Cameroon
  • Elodie Gaële Matheuda
    Natural Products Chemistry Research Unit Department of Chemistry Faculty of Science University of Dschang P.O. Box 67 Dschang Cameroon
  • Josker Nghokeng
    Natural Products Chemistry Research Unit Department of Chemistry Faculty of Science University of Dschang P.O. Box 67 Dschang Cameroon
  • Gaetan T. Tabakam
    Natural Products Chemistry Research Unit Department of Chemistry Faculty of Science University of Dschang P.O. Box 67 Dschang Cameroon
  • Raymonde A. Dzatie Djoumbissie
    Natural Products Chemistry Research Unit Department of Chemistry Faculty of Science University of Dschang P.O. Box 67 Dschang Cameroon
  • Silvère Augustin Ngouela
    Natural Products Chemistry Research Unit Department of Chemistry Faculty of Science University of Dschang P.O. Box 67 Dschang Cameroon
  • Yuan‐E Lee
    Institute of Natural Medicine University of Toyama 2630-Sugitani Toyama 930-0194 Japan
  • Mathieu Tene
    Natural Products Chemistry Research Unit Department of Chemistry Faculty of Science University of Dschang P.O. Box 67 Dschang Cameroon
  • Hiroyuki Morita
    Institute of Natural Medicine University of Toyama 2630-Sugitani Toyama 930-0194 Japan
  • Maurice Ducret Awouafack
    Natural Products Chemistry Research Unit Department of Chemistry Faculty of Science University of Dschang P.O. Box 67 Dschang Cameroon

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<jats:title>Abstract</jats:title><jats:p>A new fructofuranoside glycerol, dryoptkirbioside (<jats:bold>1</jats:bold>), along with thirteen known compounds (<jats:bold>2</jats:bold>‐<jats:bold>14</jats:bold>), was isolated from the MeOH extract of <jats:italic>Dryopteris kirbi</jats:italic> rhizomes by silica gel column chromatography, Sephadex LH‐20 column chromatography, and semipreparative HPLC. The structure of the new compound was determined by analyses of its spectroscopic data including nuclear magnetic resonance (NMR), and high‐resolution electrospray ionisation mass spectrometry (HR‐ESI‐MS) and chemical conversions. The hexane‐soluble portion and the EAF<jats:sub>A</jats:sub> fraction showed strong activities against lung (A549), breast (MCF‐7), and cervical (HeLa) human cancer cell lines (IC<jats:sub>50</jats:sub> values ranging from 4.0 to 8.8 μg/mL). Aspidinol P (<jats:bold>5</jats:bold>) and aspidinol B (<jats:bold>6</jats:bold>) exhibited moderate to low cytotoxicity on the three cell lines (IC<jats:sub>50</jats:sub> values ranging from 20.4 to 58.7 μM). The MeOH extract and hexane‐soluble portion had excellent activities against <jats:italic>Staphylococcus aureus</jats:italic> and <jats:italic>Bacillus subtilis</jats:italic> (MICs 11.7 and 23.4 μg/mL), whereas the AcOEt‐ and BuOH‐soluble portions were significantly active on <jats:italic>S. aureus</jats:italic> (MICs 46.9 and 93.8 μg/mL). The main fractions EAF<jats:sub>B</jats:sub>, EAF<jats:sub>C</jats:sub> and nBF<jats:sub>B</jats:sub> displayed excellent activity against <jats:italic>S. aureus</jats:italic> (MICs 11.7 and 23.4 μg/mL). Aspidinol B (<jats:bold>6</jats:bold>) had significant activity, while aspidinol P (<jats:bold>5</jats:bold>) was moderately active against <jats:italic>S. aureus</jats:italic> and <jats:italic>B. subtilis</jats:italic> (MICs 42.0 and 89.5 μM).</jats:p>

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