Hydrogen sulfide and polysulfides induce GABA/glutamate/d-serine release, facilitate hippocampal LTP, and regulate behavioral hyperactivity
書誌事項
- 公開日
- 2023-10-31
- 資源種別
- journal article
- 権利情報
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- https://creativecommons.org/licenses/by/4.0
- https://creativecommons.org/licenses/by/4.0
- DOI
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- 10.1038/s41598-023-44877-y
- 公開者
- Springer Science and Business Media LLC
説明
<jats:title>Abstract</jats:title><jats:p>Hydrogen sulfide (H<jats:sub>2</jats:sub>S) and polysulfides (H<jats:sub>2</jats:sub>S<jats:sub>n</jats:sub>, n ≥ 2) are signaling molecules produced by 3-mercaptopyruvate sulfurtransferase (3MST) that play various physiological roles, including the induction of hippocampal long-term potentiation (LTP), a synaptic model of memory formation, by enhancing N-methyl-<jats:sc>d</jats:sc>-aspartate (NMDA) receptor activity. However, the presynaptic action of H<jats:sub>2</jats:sub>S/H<jats:sub>2</jats:sub>S<jats:sub>n</jats:sub> on neurotransmitter release, regulation of LTP induction, and animal behavior are poorly understood. Here, we showed that H<jats:sub>2</jats:sub>S/H<jats:sub>2</jats:sub>S<jats:sub>2</jats:sub> applied to the rat hippocampus by in vivo microdialysis induces the release of GABA, glutamate, and <jats:sc>d</jats:sc>-serine, a co-agonist of NMDA receptors. Animals with genetically knocked-out 3MST and the target of H<jats:sub>2</jats:sub>S<jats:sub>2</jats:sub>, transient receptor potential ankyrin 1 (TRPA1) channels, revealed that H<jats:sub>2</jats:sub>S/H<jats:sub>2</jats:sub>S<jats:sub>2</jats:sub>, 3MST, and TRPA1 activation play a critical role in LTP induction, and the lack of 3MST causes behavioral hypersensitivity to NMDA receptor antagonism, as in schizophrenia. H<jats:sub>2</jats:sub>S/H<jats:sub>2</jats:sub>S<jats:sub>n</jats:sub>, 3MST, and TRPA1 channels have therapeutic potential for psychiatric diseases and cognitive deficits.</jats:p>
収録刊行物
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- Scientific Reports
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Scientific Reports 13 (1), 17663-, 2023-10-31
Springer Science and Business Media LLC
