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- Luc Desfrere
- Department of Medical Biochemistry and Biophysics,
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- Marie Karlsson
- Department of Medical Biochemistry and Biophysics,
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- Hiromi Hiyoshi
- Department of Medical Biochemistry and Biophysics,
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- Seth Malmersjö
- Department of Medical Biochemistry and Biophysics,
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- Evanthia Nanou
- Department of Neuroscience,
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- Manuel Estrada
- Department of Medical Biochemistry and Biophysics,
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- Ayako Miyakawa
- Department of Medical Biochemistry and Biophysics,
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- Hugo Lagercrantz
- Department of Woman and Child Health, Karolinska Institutet, SE-171 77 Stockholm, Sweden
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- Abdeljabbar El Manira
- Department of Neuroscience,
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- Mark Lal
- Department of Medical Biochemistry and Biophysics,
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- Per Uhlén
- Department of Medical Biochemistry and Biophysics,
説明
<jats:p> Dendritic growth is pivotal in the neurogenesis of cortical neurons. The sodium pump, or Na,K-ATPase, is an evolutionarily conserved protein that, in addition to its central role in establishing the electrochemical gradient, has recently been reported to function as a receptor and signaling mediator. Although a large body of evidence points toward a dual function for the Na,K-ATPase, few biological implications of this signaling pathway have been described. Here we report that Na,K-ATPase signal transduction triggers dendritic growth as well as a transcriptional program dependent on cAMP response element binding protein (CREB) and cAMP response element (CRE)-mediated gene expression, primarily regulated via Ca <jats:sup>2+</jats:sup> /calmodulin-dependent protein (CaM) kinases. The signaling cascade mediating dendritic arbor growth also involves intracellular Ca <jats:sup>2+</jats:sup> oscillations and sustained phosphorylation of mitogen-activated protein (MAP) kinases. Thus, our results suggest a novel role for the Na,K-ATPase as a modulator of dendritic growth in developing neurons. </jats:p>
収録刊行物
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- Proceedings of the National Academy of Sciences
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Proceedings of the National Academy of Sciences 106 (7), 2212-2217, 2009-02-17
Proceedings of the National Academy of Sciences
