Remdesivir Resistance in Transplant Recipients With Persistent Coronavirus Disease 2019

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  • John I Hogan
    Department of Medicine, NYU Long Island School of Medicine , Mineola, New York , USA
  • Ralf Duerr
    Department of Microbiology, NYU Grossman School of Medicine , New York, New York , USA
  • Dacia Dimartino
    Genome Technology Center, NYU Langone Health , New York, New York , USA
  • Christian Marier
    Genome Technology Center, NYU Langone Health , New York, New York , USA
  • Sarah E Hochman
    Department of Medicine, NYU Grossman School of Medicine , New York, New York , USA
  • Sapna Mehta
    Department of Medicine, NYU Grossman School of Medicine , New York, New York , USA
  • Guiqing Wang
    Department of Medicine, NYU Grossman School of Medicine , New York, New York , USA
  • Adriana Heguy
    Genome Technology Center, NYU Langone Health , New York, New York , USA

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<jats:title>Abstract</jats:title> <jats:p>New mutations conferring resistance to SARS-CoV-2 therapeutics have important clinical implications. We describe the first cases of an independently acquired V792I RNA-dependent RNA polymerase mutation developing in renal transplant recipients after remdesivir exposure. Our work underscores the need for augmented efforts to identify concerning mutations and address their clinical implications.</jats:p>

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