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- George Naifa
- Resident in Pediatrics, Department of Pediatrics, University General Hospital of Alexandroupolis, Alexandroupoli, Greece
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- George Totikidis
- NHS Registra in Pediatrics, Department of Pediatrics, University General Hospital of Alexandroupolis, Alexandroupoli, Greece
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- Sonia Alexiadou
- Resident in Pediatrics, Department of Pediatrics, University General Hospital of Alexandroupolis, Alexandroupoli, Greece
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- Christina Kolona
- Resident in Pediatrics, Department of Pediatrics, University General Hospital of Alexandroupolis, Alexandroupoli, Greece
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- Elpis Mantadakis
- Pediatrics-Pediatric Hematology/Oncology, Democritus University of Thrace Faculty of Medicine, Alexandroupoli, Thrace, Greece
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- Bibhuti Das
- editor
書誌事項
- 公開日
- 2020-10-17
- 権利情報
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- https://creativecommons.org/licenses/by/4.0/
- DOI
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- 10.1155/2020/8867621
- 公開者
- Wiley
この論文をさがす
説明
<jats:p>IgA vasculitis (formerly known as Henoch–Schönlein purpura or anaphylactoid purpura) is a usually benign vasculitis that affects children of school age. The disease is characterized by the tetrad of palpable purpura, arthralgia/arthritis, abdominal pain, and hematuria. Treatment of IgA vasculitis is mainly supportive, with administration of simple analgesics. Corticosteroids have been shown to reduce and/or ameliorate the occurrence of abdominal pain which may be severe. We present two children with IgA vasculitis and severe abdominal pain despite corticosteroid administration, who responded promptly to intravenous γ globulin (IVIg) with complete resolution of their symptoms and review of the relevant medical literature. Given the toxicity and/or need for long-term administration of other second-line immunosuppressive therapies in corticosteroid-resistant IgA vasculitis, such as rituximab, cyclosporine, cyclophosphamide, azathioprine, or colchicine, we propose that IVIg may be a useful and safe treatment option, although randomized controlled clinical trials are needed in order to clarify its role in the treatment of abdominal pain in IgA vasculitis.</jats:p>
収録刊行物
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- Case Reports in Pediatrics
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Case Reports in Pediatrics 2020 1-4, 2020-10-17
Wiley
