Aggregation Control of Gold Nanoparticles and Surface-Enhanced Raman Scattering within Giant Unilamellar Vesicles
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- Yurika Inoue
- University of Hyogo, 2167 Shosha, Himeji, Hyogo 671-2280, Japan
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- Yuto Yoshinare
- University of Hyogo, 2167 Shosha, Himeji, Hyogo 671-2280, Japan
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- Akinobu Yamaguchi
- University of Hyogo, 2167 Shosha, Himeji, Hyogo 671-2280, Japan
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- Azusa Oshima
- NTT Basic Research Laboratories and Bio-Medical Informatics Research Center, NTT Corporation, 3-1 Wakamiya, Morinosato, Atsugi, Kanagawa 243-0198, Japan
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- Masumi Yamaguchi
- NTT Basic Research Laboratories and Bio-Medical Informatics Research Center, NTT Corporation, 3-1 Wakamiya, Morinosato, Atsugi, Kanagawa 243-0198, Japan
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- Akira Heya
- University of Hyogo, 2167 Shosha, Himeji, Hyogo 671-2280, Japan
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- Koji Sumitomo
- University of Hyogo, 2167 Shosha, Himeji, Hyogo 671-2280, Japan
書誌事項
- 公開日
- 2025-03-31
- 資源種別
- journal article
- 権利情報
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- https://doi.org/10.15223/policy-029
- https://doi.org/10.15223/policy-037
- https://doi.org/10.15223/policy-045
- DOI
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- 10.1021/acs.langmuir.5c00730
- 公開者
- American Chemical Society (ACS)
この論文をさがす
説明
To detect trace molecules within giant unilamellar vesicles (GUVs), the effect of surface-enhanced Raman scattering within the vesicles was examined. Enhanced Raman spectra of a target molecule (bipyridine) within the GUVs were acquired through the encapsulation of gold nanoparticle aggregates and bipyridine. Furthermore, the introduction of gramicidin into the GUV membrane facilitated cation permeation through the lipid membrane, regulating the aggregation of gold nanoparticles. While the encapsulation of the gold nanoparticle dispersion in the GUV did not enhance the Raman signal, aggregation of gold nanoparticles, triggered by the influx of Na+ ions via gramicidin, amplified the Raman spectrum. This observation implies that molecules integrated into GUVs through vesicle fusion can aggregate with gold nanoparticles. These gold nanoparticle-encapsulated GUVs could serve as a new biosensor for detecting small amounts of molecules within the vesicles.
収録刊行物
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- Langmuir
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Langmuir 41 (14), 9567-9573, 2025-03-31
American Chemical Society (ACS)