Alterations in the GyrA Subunit of DNA Gyrase and the ParC Subunit of DNA Topoisomerase IV Associated with Quinolone Resistance in <i>Enterococcus faecalis</i>
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- Emiko Kanematsu
- <!--label omitted: 1-->Department of Urology, Gifu University School of Medicine, Gifu, Japan
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- Takashi Deguchi
- <!--label omitted: 1-->Department of Urology, Gifu University School of Medicine, Gifu, Japan
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- Mitsuru Yasuda
- <!--label omitted: 1-->Department of Urology, Gifu University School of Medicine, Gifu, Japan
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- Takeshi Kawamura
- <!--label omitted: 1-->Department of Urology, Gifu University School of Medicine, Gifu, Japan
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- Yoshinori Nishino
- <!--label omitted: 1-->Department of Urology, Gifu University School of Medicine, Gifu, Japan
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- Yukimichi Kawada
- <!--label omitted: 1-->Department of Urology, Gifu University School of Medicine, Gifu, Japan
書誌事項
- 公開日
- 1998-02
- 権利情報
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- https://journals.asm.org/non-commercial-tdm-license
- DOI
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- 10.1128/aac.42.2.433
- 公開者
- American Society for Microbiology
この論文をさがす
説明
<jats:title>ABSTRACT</jats:title> <jats:p> The <jats:italic>gyrA</jats:italic> and <jats:italic>parC</jats:italic> genes of 31 clinical isolates of <jats:italic>Enterococcus faecalis</jats:italic> , including fluoroquinolone-resistant isolates, were partially sequenced and analyzed for target alterations. Topoisomerase IV may be a primary target in <jats:italic>E. faecalis</jats:italic> , but high-level fluoroquinolone resistance was associated with simultaneous alterations in both GyrA and ParC. </jats:p>
収録刊行物
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- Antimicrobial Agents and Chemotherapy
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Antimicrobial Agents and Chemotherapy 42 (2), 433-435, 1998-02
American Society for Microbiology