Role of Oxidative Stress in Refractory Epilepsy: Evidence in Patients and Experimental Models
-
- Noemi Cardenas-Rodriguez
- Laboratory of Neurochemistry, National Institute of Pediatrics, 04530, D.F., Mexico
-
- Bernardino Huerta-Gertrudis
- Laboratory of Neurochemistry, National Institute of Pediatrics, 04530, D.F., Mexico
-
- Liliana Rivera-Espinosa
- Laboratory of Pharmacology, National Institute of Pediatrics, 04530, D.F., Mexico
-
- Hortencia Montesinos-Correa
- Department of Endocrinology, National Institute of Pediatrics, 04530, D.F., Mexico
-
- Cindy Bandala
- Unit of Support to Research, National Institute of Rehabilitation, 14389, D.F., Mexico
-
- Liliana Carmona-Aparicio
- Laboratory of Neurochemistry, National Institute of Pediatrics, 04530, D.F., Mexico
-
- Elvia Coballase-Urrutia
- Laboratory of Neurochemistry, National Institute of Pediatrics, 04530, D.F., Mexico
書誌事項
- 公開日
- 2013-01-14
- 権利情報
-
- https://creativecommons.org/licenses/by/3.0/
- DOI
-
- 10.3390/ijms14011455
- 公開者
- MDPI AG
説明
<jats:p>Oxidative stress, a state of imbalance in the production of reactive oxygen species and nitrogen, is induced by a wide variety of factors. This biochemical state is associated with systemic diseases, and diseases affecting the central nervous system. Epilepsy is a chronic neurological disorder with refractoriness to drug therapy at about 30%. Currently, experimental evidence supports the involvement of oxidative stress in seizures, in the process of their generation, and in the mechanisms associated with refractoriness to drug therapy. Hence, the aim of this review is to present information in order to facilitate the handling of this evidence and determine the therapeutic impact of the biochemical status for this pathology.</jats:p>
収録刊行物
-
- International Journal of Molecular Sciences
-
International Journal of Molecular Sciences 14 (1), 1455-1476, 2013-01-14
MDPI AG