-
- Verena J. Schuenemann
- Institute for Archaeological Sciences, University of Tübingen, 72070 Tübingen, Germany.
-
- Pushpendra Singh
- Global Health Institute, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland.
-
- Thomas A. Mendum
- Department of Microbial and Cellular Sciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford, GU2 7XH Surrey, UK.
-
- Ben Krause-Kyora
- Institute of Clinical Molecular Biology, Kiel University, 24105 Kiel, Germany.
-
- Günter Jäger
- Center for Bioinformatics, University of Tübingen, 72076 Tübingen, Germany.
-
- Kirsten I. Bos
- Institute for Archaeological Sciences, University of Tübingen, 72070 Tübingen, Germany.
-
- Alexander Herbig
- Center for Bioinformatics, University of Tübingen, 72076 Tübingen, Germany.
-
- Christos Economou
- Archaeological Research Laboratory, Stockholm University, SE-106 91 Stockholm, Sweden.
-
- Andrej Benjak
- Global Health Institute, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland.
-
- Philippe Busso
- Global Health Institute, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland.
-
- Almut Nebel
- Institute of Clinical Molecular Biology, Kiel University, 24105 Kiel, Germany.
-
- Jesper L. Boldsen
- Institute of Forensic, Antropologisk Afdelin, Medicine University of Southern Denmark, 5260 Odense S, Denmark.
-
- Anna Kjellström
- Osteoarchaeological Research Laboratory, Department of Archaeology and Classical Studies, Stockholm University, SE-106 91 Stockholm, Sweden.
-
- Huihai Wu
- Department of Microbial and Cellular Sciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford, GU2 7XH Surrey, UK.
-
- Graham R. Stewart
- Department of Microbial and Cellular Sciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford, GU2 7XH Surrey, UK.
-
- G. Michael Taylor
- Department of Microbial and Cellular Sciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford, GU2 7XH Surrey, UK.
-
- Peter Bauer
- Institute for Medical Genetics and Applied Genomics, University of Tübingen, 72076 Tübingen, Germany.
-
- Oona Y.-C. Lee
- School of Biosciences, University of Birmingham, Edgbaston, B15 2TU Birmingham, UK.
-
- Houdini H.T. Wu
- School of Biosciences, University of Birmingham, Edgbaston, B15 2TU Birmingham, UK.
-
- David E. Minnikin
- School of Biosciences, University of Birmingham, Edgbaston, B15 2TU Birmingham, UK.
-
- Gurdyal S. Besra
- School of Biosciences, University of Birmingham, Edgbaston, B15 2TU Birmingham, UK.
-
- Katie Tucker
- Department of Archaeology, University of Winchester, Sparkford Road, SO22 4NR Winchester, UK.
-
- Simon Roffey
- Department of Archaeology, University of Winchester, Sparkford Road, SO22 4NR Winchester, UK.
-
- Samba O. Sow
- Center for Vaccine Development-Mali, Ministry of Health, Centre National d’Appui à la lutte contre la Maladie–ex-Institut Marchoux, BP 251 Bamako, Mali.
-
- Stewart T. Cole
- Global Health Institute, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland.
-
- Kay Nieselt
- Center for Bioinformatics, University of Tübingen, 72076 Tübingen, Germany.
-
- Johannes Krause
- Institute for Archaeological Sciences, University of Tübingen, 72070 Tübingen, Germany.
説明
<jats:title>Leprosy: Ancient and Modern</jats:title> <jats:p> In medieval Europe, leprosy was greatly feared: Sufferers had to wear bells and were shunned and kept isolated from society. Although leprosy largely disappeared from Europe in the 16th century, elsewhere in the world almost a quarter of a million cases are still reported annually, despite the availability of effective drugs. <jats:bold> Schuenemann <jats:italic>et al.</jats:italic> </jats:bold> (p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6142" page="179" related-article-type="in-this-issue" vol="341" xlink:href="10.1126/science.1238286">179</jats:related-article> , published online 13 June; see the 14 June News story by <jats:bold>Gibbons</jats:bold> , p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6138" page="1278" related-article-type="in-this-publication" vol="340" xlink:href="10.1126/science.2013.340.6138.340_1278">1278</jats:related-article> ) probed the origins of leprosy bacilli by using a genomic capture-based approach on DNA obtained from skeletal remains from the 10th to 14th centuries. Because the unique mycolic acids of this mycobacterium protect its DNA, for one Danish sample over 100-fold, coverage of the genome was possible. Sequencing suggests a link between the middle-eastern and medieval European strains, which falls in line with social historical expectations that the returning expeditionary forces of antiquity originally spread the pathogen. Subsequently, Europeans took the bacterium westward to the Americas. Overall, ancient and modern strains remain remarkably similar, with no apparent loss of virulence genes, indicating it was most probably improvements in social conditions that led to leprosy's demise in Europe. </jats:p>
収録刊行物
-
- Science
-
Science 341 (6142), 179-183, 2013-07-12
American Association for the Advancement of Science (AAAS)
