Clinicopathological significance of <i>stanniocalcin 2</i> gene expression in colorectal cancer

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<jats:title>Abstract</jats:title><jats:p>Laser microdissection (LMD) and microarray were used to identify genes associated with colorectal cancer. <jats:italic>Stanniocalcin 2</jats:italic> (<jats:italic>STC2</jats:italic>) expression and clinicopathological significance in 139 clinical colorectal cancer samples were specifically investigated using real‐time quantitative reverse transcription‐polymerase chain reaction. A number of genes upregulated in colorectal cancer cells compared to normal colorectal epithelial cells were identified including <jats:italic>STC2</jats:italic>. <jats:italic>STC2</jats:italic> gene expression in cancer tissue was higher than in corresponding normal colorectal epithelial tissue in 124 of 139 cases (89.2%, <jats:italic>p</jats:italic> < 0.01). Tumors with high <jats:italic>STC2</jats:italic> expression showed higher frequencies of lymph node metastasis, lymphatic invasion, tumor depth, tumor size and AJCC Stage classification (<jats:italic>p</jats:italic> < 0.01). Patients with high <jats:italic>STC2</jats:italic> expression also showed significantly worse overall survival rates than those with low <jats:italic>STC2</jats:italic> expression (<jats:italic>p</jats:italic> < 0.01). Furthermore, <jats:italic>STC2</jats:italic> gene appeared to be associated with colorectal cancer progression and may be a useful prognostic indicator for colorectal cancer. © 2009 UICC</jats:p>

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